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Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131053ISBN 13: 9783838131054
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Clinical studies report that increased expression of endogenous tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is associated with decreased disease-specific survival in cancers which are resistant to TRAIL induced apoptosis. The present work investigated the role of endogenous TRAIL as an intrinsic growth factor in apoptosis-resistant human cancer cells. This less-well known effect of TRAIL was studied in the neuroblastoma cell line KELLY, a cancer cell line with intrinsic resistance to TRAIL-induced apoptosis. The functional impact of the knockdown of endogenous TRAIL was investigated by measuring cell growth and cell death after transfection: Interestingly, KELLY cells unexpectedly showed markedly reduced cell growth upon knockdown of endogenous TRAIL. Furthermore, knockdown of TRAIL induced cell death in KELLY cells, which was dependent on caspase-signaling and rescued by the addition of soluble TRAIL. Thus, the present work provided first evidence that endogenous TRAIL functions as an intrinsic survival and growth factor in KELLY cells and supports the potential of endogenous TRAIL to function as a novel therapeutic target in cancer therapy. 84 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131614ISBN 13: 9783838131610
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and a pivotal regulator of the immune response implicated in the pathogenesis of various acute and chronic inflammatory diseases. In 1993, D-dopachrome tautomerase (D-DT) was discovered during an investigation of melanogenesis. The tertiary structure of D-DT is remarkably similar to MIF, identifying D-DT as the only known eukaryotic MIF homologue discovered to date. Despite D-DT's intriguing similarities to the very well studied MIF, there have been very few reports on the biological functions and mechanisms of action of D-DT. This dissertation aimed at the functional characterization of D-DT in biological and pathophysiologic conditions. 100 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131215ISBN 13: 9783838131214
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -We can only control what we can measure. In the case of dairy farming, nitrogen utilisation requires a higher level of control to reduce environmental pollution and improve farm economics. Nitrogen metabolism in the ruminant animal is a complicated system and accurate evaluation of protein utilisation by dairy cows is limited by current methods. This dissertation assesses various methods of analysing ruminal crude protein degradation and introduces a new method of assessing protein value of forages i.e. the protein available to the ruminant for absorption at the duodenum. The following procedures are included: in situ incubation, Cornell Net Carbohydrate and Protein System, in vitro enzymatic degradation and the modified Hohenheim gas test. The third section of this dissertation applies these methods to a controlled experiment investigating the effect of wilting on the protein value, protein characteristics and amino acid profile of grass silage. Conclusively, the results of this study aid in estimating protein supply from forages to dairy cows. 92 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838117662ISBN 13: 9783838117669
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Local inter neurons make up a considerable portion of the brain. But what are they good for What are their functions and properties In this dissertation local inter neurons in the primary olfactory center of the honey bee are investigated by means of electro-physiology, morphology and computational analysis. Every single one of these approaches reveals both remarkable diversity of this neuron family, as well as trends to form meaningful groups. 84 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838130960ISBN 13: 9783838130965
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Membrane proteins play critical roles in diverse cellular processes such as energy conversion, cellular transport, signal transduction and cell division. Many bacterial inner membrane proteins are co-translationally inserted into the membrane, in most cases by the well-studied Sec pathway using signal recognition particle and the SecYEG protein insertion channel. The more recently discovered YidC/Oxa1 membrane protein insertion system represents an alternative to the canonical Sec Pathway. How do the protein insertion mechanisms compare How are the two insertion systems connected The Author Rebecca Kohler presents an introductory overview of co-translational membrane protein insertion and discusses the characteristics of the Sec and YidC/Oxa1 insertion systems. A structural and functional study of the YidC/Oxa1 system forms the basis for the following analysis. This book addresses researchers and students in life sciences as well as scientific employees in the biotech industry. 84 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131363ISBN 13: 9783838131368
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the discovery of spin torque in 1996, independently by Berger and Slonczewski, and given its potential impact on information storage and communication technologies, (e.g. through the possibility of switching the magnetic configuration of a bit by current instead of a magnetic field, or the realization of high frequency spin torque oscillators (STO)), this effect has been an important field of spintronics research. One aspect of this research focuses on ferromagnets with low damping. The lower the damping in a ferromagnet, the lower the critical current that is needed to induce switching of a spin valve or induce precession of its magnetization. NiMnSb with its good properties, namely low magnetic damping in combination with a high spin-polarization, is a promising candidate for such devices. 120 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131371ISBN 13: 9783838131375
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Lung cancer is the leading cause of all cancer related deaths worldwide. The 5-year survival rate ranges from 80% in early stages to less than 5% in advanced disease. Non-small cell lung carcinoma (NSCLC) accounts for 80% of all lung malignancies, 40% of which are adenocarcinomas representing one of the most common lung cancer subtypes. Currently, prognosis is mostly determined based on the extension of disease at diagnosis. Thereby it has become evident that predicted and real outcomes can vary significantly, even for patients with the same stage of disease. Thus, novel biomarkers that refine prognosis with a reliable clinical significance are clearly needed. Therefore we aimed to implement an activity-based proteomics platform representing a powerful tool in the search for novel disease biomarkers. 120 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838130286ISBN 13: 9783838130286
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Rezidivierende Kopfschmerzen im Kindesalter stellen ein großes Gesundheitsproblem dar. Trotz des hohen diagnostischen Stellenwerts für die klinische Praxis liegen erst seit den Achtziger Jahren Untersuchungen zur Schmerzbewältigung bei Kindern vor. Für Erwachsene konzipierte Interventionstechniken zur Schmerzbewältigung wurden bisher ohne Rücksicht auf entwicklungsspezifische Unterschiede den Kindern vermittelt. Im Hinblick auf die Relevanz dieses Themas werden von Hildegard Lüdecke erstmals Referenzdaten von Kindern im Alter von 9-10 Jahren spontan generierte Copingstrategien bei Kopfschmerzen geliefert. Gibt es einen geschlechtsspezifischen Unterschied in Bezug auf das Bewältigungsverhalten bei rezidivierenden Kopfschmerzen Ist die Schmerzintensität oder die gesundheitsbezogene Lebensqualität relevant für die Wahl einer bestimmten Copingstrategie Das Ergebnis der Studie zeigt, dass Viertklässler als häufigste Bewältigungsstrategie bei Kopfschmerzen pharmakologische Mittel und Entspannungstechniken angeben. Darauf bezugnehmend werden die medikamentösen und nichtmedikamentösen Therapie- und Prophylaxemaßnahmen bei Migräne und Kopfschmerzen im Kindesalter aufgeführt und bewertet 112 pp. Deutsch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131231ISBN 13: 9783838131238
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This work focuses on the determination of noble gas temperatures (NGTs) in water inclusions in stalagmites with the aim to infer the cave temperature prevailing at the time the inclusions were formed. The method is based on the temperature-dependent solubilities of noble gases (He, Ne, Ar, Kr and Xe) in water, which allows calculating the water temperature from measured noble gas concentrations if the salinity and the atmospheric pressure during gas exchange are known.Stalagmites are increasingly being used as climate archives, as they provide highly resolved and well-dated records of past climate conditions over glacial-interglacial time intervals. Stalagmites contain 0.01-0.1 wt.% of water, which is incorporated into the calcite crystals in the form of water inclusions during stalagmite growth. Noble gas analysis in water inclusions in stalagmites hence offers the potential to directly and quantitatively determine cave temperatures, which is an important prerequisite for the interpretation of stable isotope records in the stalagmite calcite. 112 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131541ISBN 13: 9783838131542
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the theory of false vacuum eternal inflation the false vacuum decays whenever the inflaton potential has multiple minima. The decay means a nucleation of a bubble with a different density in vacuum energy. Inflation may occur within the bubble eventually giving way to the hot big bang with a subsequent evolution that is consistent with current observations. Interest in this picture has recovered as it became generally accepted that a compactification of the extra dimensions in string theory leads to an effective potential with a vast number of minima, the landscape of string theory. In the first part of this thesis the effects that can be expected if the surrounding of the bubble is dynamical are elucidated. In particular, it is shown how the bubble evolves in the presence of a fluid in the background, and moreover, the effects of a radial inhomogeneity in energy density and spatial curvature. Second, collisions of bubbles would disturb the homogeneity and isotropy of their interior, which, in turn, could lead to observable effects in the cosmic microwave background radiation. It will be clarified whether Minkowski functionals are a promising tool to detect such signals. 112 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131118ISBN 13: 9783838131115
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Stroke is the third largest cause of death after cardiovascular diseases and cancer and is a major factor of permanent disability in most industrial countries. Disparities exist in access to healthcare services due to geographical barriers and limited resources. Rural locations often lack the resources for adequate stroke management. The idea of telestroke is to transfer knowledge and expertise of acute stroke management into areas with limited neurological services. The first part in this dissertation mainly covers the evidence of telestroke. The second part is an evaluation of a telestroke network in Salzburg, Austria. The aim is to assess the safety and effectiveness of intravenous thrombolysis application via a real time two-way videoconferencing system combined with a teleradiological procedure followed by transfer to a specialised stroke unit. 64 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131649ISBN 13: 9783838131641
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Tissue engineering is a novel and promising approach to repair articular cartilage defects. This procedure requires that autologous articular chondrocytes are isolated from a small biopsy, expanded in vitro on two-dimensional culture plates to augment their original number and then cultured onto specific three-dimensional synthetic biomaterials to generate implantable cartilaginous constructs. The phase of cell expansion is critical, since for such technique large number of chondrocytes is needed. We thus aimed our research at devising a mathematical model to deeply understand the growth dynamics of chondrocytes. Experimentally, it was observed that when the cells in culture reach a critical level, they spontaneously tend to align along some common axis of orientation. Our intention in this book is to study the parameter regimes which lead to the formation of one or more patterns, and to compare them to the experiments. With this goal in mind we implemented simulations of the three dimensional model by a combination of Tchebychef method, finite differences and trapezoidal rule and perform experiments to approximate some of the parameters. 104 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131134ISBN 13: 9783838131139
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Agricultural operations affect the soil's capability for water infiltration and storage. In this doctoral thesis, agricultural impacts in terms of soil compaction and different tillage techniques on the soil hydraulic properties and the water-conducting pores were analyzed. In the first part, infiltration measurements in differently compacted subsoil treatments of an arable field in Lincoln/New Zealand were used to characterize the effects on the soil's porosity and its associated water-conducting properties. In the second part, the impact of different tillage techniques - conventional (CT), reduced (RT), and no-tillage (NT) - on the hydraulic properties of an arable field in Raasdorf/Austria and its temporal dynamics were captured by repeated measurements. In the third part, data from the tillage study was used to parameterize a soil water simulation with constant and time-variable hydraulic parameters. The results of this thesis give evidence that soil hydraulic properties are strongly altered by soil compaction and different tillage operations. The thesis also shows the importance of temporal variations of soil hydraulic properties and its incorporation in hydrological models. 96 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838130588ISBN 13: 9783838130583
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -To date, there is a growing body of evidence that diet might influence the development and functioning of the brain, which, in turn, has an effect on mental state and performance. Since parents are seen as the gatekeepers to a child's diet and provide the key environment for the development of a child's eating behaviours, they constitute an important group of consumers for nutritional communication through policies, public health intervention programmes and health claims about functional food products. The author, Brigitte Brands, using three different methodological approaches, aims to qualitatively and quantitatively examine the current perceptions and beliefs of parents about the relationship between what children eat and their mental development, state and performance. Building from an introductory overview of contemporary research, parental perceptions are evaluated and discussed in the light of public health importance and consumer science. This work has been conducted in the context of an EU funded initiative which aims to further our understanding of the effect of nutrition on the mental development and performance in children (nutrimenthe.eu). 104 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838129776ISBN 13: 9783838129778
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Mobbing bei der Polizei ist nach wie vor ein aktuelles Thema, wie es das auch in anderen Organisationen ist. Die hier vorgelegte empirische Untersuchung dokumentiert die theoretische Auseinandersetzung mit der Fragestellung im Rahmen eines Psychologie-Projektes mit Studierenden der Berliner Polizei. Es wurde ein Fragebogen entwickelt und, nach dem Bewältigen polizei-bürokratischer Hürden, eingesetzt, Auswertungskategorien definiert und damit die Fragebogendaten ausgewertet. Die Ergebnisse zeigen ein auffällig hohes Vorkommen von Mobbing innerhalb der Institution, dem eine Fülle von präventiven Vorschlägen der befragten KollegInnen der Berliner Polizei gegenübersteht. Die geschlechtspezifischen Ergebnisse sind sehr beeindruckend, insbesondere das Risiko von Frauen bei der Polizei, Mobbingopfer zu werden, vor allem als Führungskraft. Das vom Autor nicht selbst ausgelöste Medienecho führte zur temporären Dialogverweigerung der Polizeispitze gegenüber der Hochschule und dem Autor. 160 pp. Deutsch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131452ISBN 13: 9783838131450
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Visuelle Informationen sind nicht nur für die Wahrnehmung, sondern auch für die Reaktion auf die Umwelt bedeutend. Die Verarbeitung visuell aufgenommener Informationen für motorische Antworten wird als visuomotorische Integration bezeichnet. Ein Verständnis der neuronalen Prozesse, die die Umsetzung visueller Informationen in eine motorische Handlung bewirken, ist von grundlegendem Interesse. Die Autorin Barbara Wolynski untersuchte in zwei Ansätzen die visuomotorische Integration beim Menschen. Mit Hilfe der funktionellen Magnetresonanztomographie wurden zunächst in Normalprobanden relevante kortikale Regionen identifiziert und dann die Funktion und Plastizität der visuomotorischen Verarbeitung bei abnormalem visuellen Eingang an Albinismuspatienten untersucht. Dabei trägt die Untersuchung des Krankheitsbildes Albinismus nicht nur zur Erforschung der Krankheit selbst, sondern auch zu einem besseren Verständnis des entsprechenden Prozesses im Gehirn von Normal-probanden bei. Das Buch richtet sich an Interessierte an der Erforschung des Gehirns und an Neurowissenschaftler. 148 pp. Deutsch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131061ISBN 13: 9783838131061
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In Geosciences inferences on processes are usually derived from irregularly measured data in both space and time. Such empirical time series are often characterized by changing boundary conditions, nonlinearity and uncertainty. Hence, phenomenological knowledge of processes is indispensable in order to derive physically meaningful equations describing the underlying dynamical system. However, unambiguous inferences prove to be difficult when nonlinearity and non-stationarity are present. In contrast to numerical models, data-driven models are specifically built to be parsimonious with a minimal set of adjustable parameters, intended to reproduce the statistical properties of signals. This dissertation focuses on the fundamental aspects of uncertainty estimation of nonlinear data-driven prediction methods. Within this framework, the essential factors in the model development process are emphasized and discussed on the basis of both climatological and hydrological time series. A key issue of the thesis is whether the analysis of uncertainties might contribute to process understanding and eventually support the optimization of data-driven models. 160 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 383810823XISBN 13: 9783838108230
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This thesis gives new insights to the field of current- and field-induced domain wall dynamics phenomena in nanopatterned elements and of the role of the different energy terms to the spin configuration of half-metallic systems. Time resolved imaging allows for the determination of the effective domain wall mass and the underlying physical origins. In current-induced domain wall displacement experiments, the influence of edge roughness-induced pinning was identified as having a big influence on the critical current density that is needed to displace a domain wall in a magnetic micro- or nanowire. By applying a specially developed patterning method, the domain wall pinning at edge defects was highly reduced and the device performance was improved by a factor of four, compared to conventionally produced wires. Patterning methods for ferromagnetic half-metals were also developed and the spin structure of structured elements are characterized. 156 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838125339ISBN 13: 9783838125336
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Bacillus amyloliqufaciens FZB42 has been known as PGPR which has an impressive effect to improve plant growth. It produces not only vast array of secondary metabolites with antibacterial and antifungal activities, but also produces the plant hormone IAA. Although many mechanisms have been elucidated, our knowledge about basic molecular mechanisms responsible for its beneficial action is far from complete. In this study, transposon mutagenesis based on mariner tranposon was applied to generate tranposon library which then was screened to identify the genes involved in plant growth-promoting activity. Three mutants that were impaired in their ability to colonize plant surface due to defects in biofilm formation and swarming motility were found. One mutant (degU mutant) showed defect in biofilm formation and swarming motility, as well, two mutants (yusV mutant and pabB mutant) impaired in biofilm formation were confirmed by complementation and retransformation. Screening by the Lemna biosystem and further assays with A. thaliana revealed three genes responsible for reduction in plant growth promoting activity of B. amyloliqufaciens FZB42. 136 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131282ISBN 13: 9783838131283
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The work connects the fields of Elementary Particle-, Collider- and Astrophysics. A thermodynamic model of the quark-gluon plasma using quasiparticle degrees of freedom based on the hard thermal loop self-energies is introduced. It provides a link between an established quasiparticle model - following from the former using a series of approximations - and QCD - from which the former is derived using the Cornwall-Jackiw-Tomboulis formalism and a special parametrization of the running coupling. Both models allow for an extrapolation of first-principle QCD results available at small chemical potentials using Monte-Carlo methods to large net baryon densities with remarkably similar results. They are used to construct equations of state for heavy-ion collider experiments at SPS and FAIR as well as quark and neutron star interiors. A mixed-phase construction allows for a connection of the SPS equation of state to the hadron resonance gas including an extension to the weak sector. From the extrapolation of the most recent lattice results the existence of bound pure quark stars is not suggested. However, quark matter might exist in a hybrid phase in cores of neutron stars. 156 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131045ISBN 13: 9783838131047
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Elektronisch angeregte Zustände organischer Halbleiter spielen für das Verständnis von organischen Solarzellen, organischen Lasern und organischen Leuchtdioden, sogenannten OLEDs (Organic Light Emitting Diodes), eine zentrale Rolle. Die Berechnung der Übergänge zwischen diesen angeregten Zuständen ist jedoch nicht einfach, da Methoden mit geringem Rechenaufwand unzureichende Ergebnisse liefern und genauere Methoden einen zu hohen Rechenaufwand für große Moleküle haben. In dieser Arbeit beschreibt der Autor sowohl methodische Weiterentwicklungen im Rahmen der ab initio zweiter Ordnungsmethoden CC2 und ADC(2) als auch Anwendungen dieser Weiterentwicklungen auf aktuelle Fragestellungen. Die methodischen Erweiterungen stehen dabei hauptsächlich im Zusammenhang mit Übergangsmomenten zwischen angeregten Zuständen. Durch die Implementierung der selbigen ist nun die Berechnung transienter Absorptionsspektren möglich. Die Anwendungen behandeln vorwiegend das Feld der organischen Halbleiter und deren photo-elektronische Eigenschaften. Ein Fokus liegt dabei auf den bislang wenig erforschten Triplett-Excimeren. 148 pp. Deutsch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131436ISBN 13: 9783838131436
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Multiple activities taking place at the landscape scale is indepensible to nature protection reqiring a system modelling approach of multi-agents on the landscale scale. This book presents results of a doctorate research of the first attempt on the use of Petri nets to modell and simulute ecosytem services unsing a system modelling approach of multi-agents at the landscape scale. It provides an estimation, management scheme and community-based financial participation models with Petri nets and coupled them as a unified Petri net for management support systems for preserving ecosystem services at the landscpe scale. A real scenario application at the UNESCO Biosphere Reserve Spreewald is given. Community-based financial participation is also developed within the framework of the research as a new concept for encouraging community-based participation and funding in developmental initials to enhance sustainability in the society. The book can be useful for ecosystems developers, students, researchers, the business community, governmental and consulting agencies, international and funding organisations and local communities as well. 124 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838130944ISBN 13: 9783838130941
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Higgs boson is a central part of the electroweak theory and is crucial to generate masses for fermions and the weak gauge bosons. Here, the basis to compute the physical quantities is the path integral which is evaluated by means of Monte Carlo simulations thus allowing for fully non perturbative calculations. The chiral symmetry of the electroweak model is incorporated by using the Neuberger overlap operator. Results from lattice perturbation theory up to one loop of the Higgs boson propagator are compared with those obtained from Monte Carlo simulations. At all values of the investigated couplings, the perturbative results agree very well with the Monte Carlo data. The Higgs boson does not appear as an asymptotic stable state but as a resonance. A main focus of this work is the investigation of the resonance parameters of the Higgs boson. The resonance width and the resonance mass are investigated at weak and at large quartic couplings. Finally, the effect of a heavy fourth generation of fermions on the upper and lower Higgs boson is studied. Both mass bounds are revised in the presence of a quark doublet with a mass around 700 GeV. 160 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 383813107XISBN 13: 9783838131078
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Poly(ADP-ribosyl)ation is a posttranslational modification of cellular proteins mostly catalysed by poly(ADP-ribose) polymerase-1 (PARP-1) and to a lesser extent by PARP-2. The study aimed to explore the role of PARP-1 in DNA repair and cell death using in vitro as well as in vivo models and contributed to the potential use of a novel highly-selective PARP-1 inhibitor, which provides a valuable tool to dissect different roles of PARP-1 and PARP-2 in cellular functions. Overexpression of human PARP-1 (hPARP-1) in rodent cells resulted in an increased DNA repair capacity after X-irradiation, but also to an increased susceptibility to DNA damage in response to alkylating agents or PARP inhibition. Novel transgenic mice with intended tissue-specific overexpression of hPARP-1 were generated and characterized on a genetic level. Unexpectedly, despite cell culture validation of the expression construct and transgene expression on the mRNA level, no protein expression of the transgene could be detected in these mice for largely unknown reasons. This outcome needs to be considered in future approaches aiming to generate hPARP-1 transgenic mice. 132 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838130731ISBN 13: 9783838130736
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Personzentrierte Berater/-innen und Therapeut/innen sind von ihrem originären Ansatz her für ein dyadisches Setting ausgebildet worden: Ein Klient spricht mit einem Berater. Dies beinhaltet auch die von Carl R. Rogers zu Grunde gelegte individuelle Persönlichkeitstheorie. Eine beträchtliche Zahl personzentrierter Berater/-innen arbeiten aber heute in der Familienberatung, also in einem Bereich, in welchem ihnen nicht nur ein Mensch gegenüber sitzt, sondern eine ganze Familie. Torsten Ziebertz geht der Frage nach, welche theoretischen Annahmen die Berater/-innen haben, wen sie da eigentlich beraten. In einer empirischen Studie werden insgesamt 40 personzentrierte Familienberater/-innen zu ihren theoretischen Annahmen befragt. Die inhaltsanalytische Auswertung dieser Interviews verdeutlicht die Theoriedefizite in diesem Bereich, und zeigt, mit welchen Versatzstücken die Praktiker diese Lücken füllen. Das Buch wendet sich an praktisch arbeitende (personzentrierte) Familienberater/-innen, sowie an Wissenschaftler aus den Bereichen Familientheorien und Personzentrierter Theorie. 188 pp. Deutsch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 383813124XISBN 13: 9783838131245
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Die Alternaria-Toxine Alternariol (AOH) und Alternariol-9-methylether (AME) werden häufig in Lebensmitteln nachgewiesen und gelten als genotoxisch und mutagen in vitro. Derzeit existieren keine gesetzlichen Regelungen für Höchstmengen in Lebensmitteln, da die momentane Datenlage für eine Risikobewertung nicht ausreicht. In dieser Arbeit wurden daher in vitro-Untersuchungen zur Resorption, zum Metabolismus und zur Mutagenität von AOH und AME durchgeführt. Die Autorin konnte unter anderem zeigen, dass insbesondere AOH sehr gut resorbiert wird und der oxidative Metabolismus der beiden Toxine in vivo-Relevanz besitzt. Die dabei entstehenden Metaboliten sind auf Grund ihrer Reaktivität möglicherweise von toxikologischer Bedeutung. Untersuchungen hinsichtlich des mutagenen Potentials von AOH und AME ergaben trotz der strukturellen Ähnlichkeit der beiden Verbindungen signifikante Unterschiede. Insgesamt leistet diese Arbeit einen wesentlichen Beitrag zum besseren Verständnis der Toxikokinetik und -dynamik von AOH und AME und kann als Grundlage für eine zukünftige Bewertung des gesundheitlichen Risikos dieser beiden Mykotoxine dienen. 164 pp. Deutsch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838131746ISBN 13: 9783838131740
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Over the last years, researchers and engineers have developed numerous abstractions and programming models that make developing parallel programs easier, safer, and more efficient. Despite the advances made in parallel programming, however, the corresponding compilers still remain largely ignorant of the parallelism exhibited by the program execution. In particular, current compilers do not have any knowledge about what tasks are scheduled with what ordering---even though many higher-level parallel programming models contain a wealth of task-order information that can be exploited by the compiler. This thesis presents a schedule analysis that can extract task-ordering information from real-world programs. By analyzing potential orderings between tasks, the compiler can decide whether accesses to shared memory by different tasks may interfere and use this information to guide its optimization efforts. The schedule analysis can be combined with standard program analyses such as points-to and escape analysis to improve the precision of known optimizations as well as enable new optimizations. 180 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838117220ISBN 13: 9783838117225
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -For improved flood management, hydrologists in crisis committees need the most current information in a customizable, dynamic and geo-referenced form to better advise their peers or the public. Increase of lead time is achieved by providing interactive, visual methods in a cartographic monitoring infrastructure, allowing hydrologists to retrieve and bundle their desired flood information in a time-saving way. Vast amounts of real-time data are valorized by novel methods which facilitate their integrated, interactive and individual use in time-critical hydrological situations. Novel data modeling and data access methods are introduced for real-time and large time series data. The involved problems are tackled by (1) a central spatiotemporal database which handles historical, real-time and forecast data, by (2) a decentralized Web-based cartographic user interface, i.e., by providing maps to access data, and by (3) various interactive tools on this interface for map manipulation and data exploration. 200 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838130928ISBN 13: 9783838130927
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The future PANDA experiment will perform studies of the strong interaction in the charm quark sector. The Micro-Vertex-Detector (MVD) as innermost part of the tracking system plays a key role for most of the planned experiments. It will be equipped with silicon pixel and microstrip detectors. The edition starts with a brief introduction to main physics aspects and a detailed review on the experimental status for the complete charm spectrum. Afterwards, all relevant details of the PANDA experiment are summarized. Central part of this work is the design optimization for the PANDA MVD. The reader can follow the development from a conceptual design towards a solution for the final detector assembly. During this process, a comprehensive and realistic detector model is being developed, which on the one hand fulfils the physics requirements and on the other hand sustains feasible engineering solutions. The final part contains a compilation of extended simulations with the developed detector model starting from the determination of basic detector parameters to the full simulation of physics channels. 200 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften Feb 2012, 2012
ISBN 10: 3838130146ISBN 13: 9783838130149
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The first part of this work addresses the importance of shear flows in astrophysical gas dynamics, where the evolution of the Kelvin-Helmholtz instability (KHI) is studied analytically and numerically. The dispersion relation for the two-dimensional KHI including viscous dissipation is derived. The resulting expression for the growth rate is then used to estimate the intrinsic viscosity of four numerical schemes depending on code-specific as well as on physical parameters. The second part of this work focuses on the importance of forthcoming CMB measurements and their corresponding implications for cosmology. The theoretical CMB-cross correlation bispectrum (between the Rees-Sciama and weak lensing effect) together with the corresponding signal-to-noise ratio are analyzed for dark energy models with a time varying equation of state - the quintessence. The main focus is on a special form of quintessence, called early dark energy. The theoretical predicted signals give insight if future experiments are able to distinguish between quintessence and the standard cosmological constant. 164 pp. Englisch.