springer new york dez 2009 (43 results)

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The genesis of modern searches for observable meteoritic phenomena on the Moon is the paper by Lincoln La Paz in Popular Astronomy magazine in 1938. In it he argued that the absence of observed fashes of meteoritic impacts on the Moon might be interpreted to mean that these bodies are destroyed as luminous meteors in an extremely rarefed lunar atmosphere. The paper suggested the possibility of systematic searches for such possible lunar meteors. With these concepts in mind, I was surprised to note a transient moving bright speck on the Moon on July 10, 1941. It appeared to behave very much as a lunar meteor would - except that the poorly estimated duration would lead to a strongly hyperbolic heliocentric velocity. Thus, the idea of systematic searches for both p- sible lunar meteors and meteoritic impact fashes was born. It was appreciated that much time might need to be expended to achieve any positive results. Systematic searches were carried out by others and myself chiefy in the years 1945-1965 and became a regular program at the newly founded Association of Lunar and Planetary Observers, or ALPO. 256 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This text is structured in a problem-solution format that requires the student to think through the programming process. New to the second edition are additional chapters on suffix trees, games and strategies, and Huffman coding as well as an Appendix illustrating the ease of conversion from Pascal to C. 288 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Description:In biomedical research, because of a dramatic increase in productivity, immunocytochemistry has emerged as a major technique. The proposed book will provide the first practical guide to planning, performing, and evaluating immunocytochemical experiments. In today's graduate education the emphasis is on doing research and not on formal class work. Graduate students therefore lack the background in many essential techniques necessary to perform research in fields in which they were not trained. As director of a university core microscopy facility which sees students and faculty from dozens of laboratories each year, Dr. Burry has surmised the vast majority of these novice microscope users need considerable help. In an attempt to educate users, Dr. Burry has initiated immunocytochemistry seminars and workshops which serve to train people in this powerful research tool. The proposed book is an outgrowth of these presentations and conversations with, by now, hundreds of people who have asked for help.The philosophy which separates this book from other books in this field is that it is practical, rather than academic. In looking at other important immunocytochemistry titles, the predominant orientation is academic, with the author attempting to comprehensively discuss the topic. For example, one book with sample preparation lists ten fixatives which can be used; however, only two such fixatives are commonly used today. In this particular title, the detailed discussion of old methods might be seen as important in establishing the author as an expert. By contrast, the approach for Burry's book would be to discuss methods based on what works in animal research laboratories today, and focus only on the most productive methods.An additional distinction with this proposed book is the focus on animal research and not human pathology. There is a certification program for pathology technicians which requires them to learn a set body of material based on processing human tissue for examination by a pathologist. Many of the books on immunocytochemistry aim at this large pathology user base. Due to historical reasons, pathology laboratories process human tissues in a specific way and embed the tissue in paraffin, as has been done for over a century. In the last ten years, the power of immunocytochemistry in clinical diagnosis has become clear and has accordingly been adapted to pathology. However, the extensive processing needed for paraffin sections is not needed if the tissues are from research animals. Processing for animal-based tissues takes about a third of the time and results in higher quality images. The focus of this book is on processing these animal research tissues for immunocytochemistry. Today, there are no technique books which are aimed at this user base.As a subject matter expert in the area of the proposed book, Dr. Burry will make recommendations and offer opinions. Because this field is new and is emerging, there are numerous advantages of specific methods over other, more generalized methods. The purpose of this book is to show a novice how to do immunocytochemistry without engaging in a discussion of possible advanced methods. For the advanced user, there are several good books which discuss the unusual methods, yet for the novice there are currently none. Main Author :Richard W. Burry, The Ohio State University (United States).The Outline of the Book: Each chapter supplies a set of important principals and steps necessary for good immunocytochemistry. The information is distilled down to include only the most important points and does not attempt to cover infrequently used procedures or reagents. At the end of most chapters is a section on trouble-shooting many of the common problems using the Sherlock Holmes method. Each chapter also includes specific protocols which can be used. The goal of each chapter is to present the r 240 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Inventories are prevalent everywhere in the commercial world, whether it be in retail stores, manufacturing facilities, government stockpile material, Federal Reserve banks, or even your own household. This textbook examines basic mathematical techniques used to sufficiently manage inventories by using various computational methods and mathematical models.The text is presented in a way such that each section can be read independently, and so the order in which the reader approaches the book can be inconsequential. It contains both deterministic and stochastic models along with algorithms that can be employed to find solutions to a variety of inventory control problems.With exercises at the end of each chapter and a clear, systematic exposition, this textbook will appeal to advanced undergraduate and first-year graduate students in operations research, industrial engineering, and quantitative MBA programs. It also serves as a reference for professionals in both industry and government worlds. The prerequisite courses include introductory optimization methods, probability theory (non-measure theoretic), and stochastic processes. 360 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This text is structured in a problem-solution format that requires the student to think through the programming process. New to the second edition are additional chapters on suffix trees, games and strategies, and Huffman coding as well as an Appendix illustrating the ease of conversion from Pascal to C. 288 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Concise Encyclopedia of Statistics presents the essential information about statistical tests, concepts, and analytical methods in language that is accessible to practitioners and students of the vast community using statistics in medicine, engineering, physical science, life science, social science, and business/economics. The reference is alphabetically arranged to provide quick access to the fundamental tools of statistical methodology and biographies of famous statisticians. The more than 500 entries include definitions, history, mathematical details, limitations, examples, references, and further readings. All entries include cross-references as well as the key citations. The back matter includes a timeline of statistical inventions. This reference will be an enduring resource for locating convenient overviews about this essential field of study. 636 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This self-contained textbook gives a thorough exposition of multivariable calculus. The emphasis is on correlating general concepts and results of multivariable calculus with their counterparts in one-variable calculus. Further, the book includes genuine analogues of basic results in one-variable calculus, such as the mean value theorem and the fundamental theorem of calculus.This book is distinguished from others on the subject: it examines topics not typically covered, such as monotonicity, bimonotonicity, and convexity, together with their relation to partial differentiation, cubature rules for approximate evaluation of double integrals, and conditional as well as unconditional convergence of double series and improper double integrals. Each chapter contains detailed proofs of relevant results, along with numerous examples and a wide collection of exercises of varying degrees of difficulty, making the book useful to undergraduate and graduate students alike. 488 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Traditional logic as a part of philosophy is one of the oldest scientific disciplines and can be traced back to the Stoics and to Aristotle. Mathematical logic, however, is a relatively young discipline and arose from the endeavors of Peano, Frege, and others to create a logistic foundation for mathematics. It steadily developed during the twentieth century into a broad discipline with several sub-areas and numerous applications in mathematics, informatics, linguistics and philosophy.This book treats the most important material in a concise and streamlined fashion. The third edition is a thorough and expanded revision of the former. Although the book is intended for use as a graduate text, the first three chapters can easily be read by undergraduates interested in mathematical logic. These initial chapters cover the material for an introductory course on mathematical logic, combined with applications of formalization techniques to set theory. Chapter 3 is partly of descriptive nature, providing a view towards algorithmic decision problems, automated theorem proving, non-standard models including non-standard analysis, and related topics.The remaining chapters contain basic material on logic programming for logicians and computer scientists, model theory, recursion theory, Gödel's Incompleteness Theorems, and applications of mathematical logic. Philosophical and foundational problems of mathematics are discussed throughout the text. Each section of the seven chapters ends with exercises some of which of importance for the text itself. There are hints to most of the exercises in a separate file Solution Hints to the Exercises which is not part of the book but is available from the author's website. 344 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Education is an admirable thing, but it is well to remember from time to time that nothing worth knowing can be taught. Oscar Wilde, 'The Critic as Artist,' 1890. Analysis is a profound subject; it is neither easy to understand nor summarize. However, Real Analysis can be discovered by solving problems. This book aims to give independent students the opportunity to discover Real Analysis by themselves through problem solving. ThedepthandcomplexityofthetheoryofAnalysiscanbeappreciatedbytakingaglimpseatits developmental history. Although Analysis was conceived in the 17th century during the Scienti c Revolution, it has taken nearly two hundred years to establish its theoretical basis. Kepler, Galileo, Descartes, Fermat, Newton and Leibniz were among those who contributed to its genesis. Deep conceptual changes in Analysis were brought about in the 19th century by Cauchy and Weierstrass. Furthermore, modern concepts such as open and closed sets were introduced in the 1900s. Today nearly every undergraduate mathematics program requires at least one semester of Real Analysis. Often, students consider this course to be the most challenging or even intimidating of all their mathematics major requirements. The primary goal of this book is to alleviate those concerns by systematically solving the problems related to the core concepts of most analysis courses. In doing so, we hope that learning analysis becomes less taxing and thereby more satisfying. 264 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This practical book is ideal for readers who want to rapidly determine the appropriate imaging for pediatric patients. The text provides a concise and accessible summary of the literature on how and when to use imaging studies. Chapters address the essentials, such as cost-effectiveness, and are written in collaboration by renowned specialists in the fields of pediatrics and pediatric radiology. Topics cover common clinical scenarios in neuroimaging and musculoskeletal, chest, and abdominal imaging. Each imaging recommendation is presented along with the supporting data and the strength of the evidence. 688 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Holistic Engineering Education: Beyond Technologyis a compilation of coordinated and focused essays from world leaders in the engineering profession who are dedicated to a transformation of engineering education and practice. The contributors define a new and holistic approach to education and practice that captures the creativity, interdisciplinarity, complexity, and adaptability required for the profession to grow and truly serve global needs. With few exceptions today, engineering students and professionals continue to receive a traditional, technically-based education and training using curriculum models developed for early 20th century manufacturing and machining. While this educational paradigm has served engineering well, helping engineers create awe-inspiring machines and technologies for society, the coursework and expectations of most engineering programs eschew breadth and intellectual exploration to focus on consistent technological precision and study. Why this dichotomy While engineering will always need precise technological skill, the 21st century innovation economy demands a new professional perspective that recognizes the value of complex systems thinking, cross-disciplinary collaborations, economic and environmental impacts (sustainability), and effective communication to global and community leaders, thus enabling engineers to consider 'the whole patient' of society's needs. The goal of this book is to inspire, lead, and guide this critically needed transformation of engineering education. 'Holistic Engineering Education: Beyond Technology points the way to a transformation of engineering education and practice that will be sufficiently robust, flexible, and systems-oriented to meet the grand challenges of the 21st century with their ever-increasing scale, complexity, and transdisciplinary nature.'-- Charles Vest, President, National Academy of Engineering; President Emeritus, MIT'This collection of essays provides compelling arguments for the need of an engineering education that prepares engineers for the problems of the 21stcentury. Following the National Academy's report on the Engineer of 2020, this book brings together experts who make the case for an engineering profession that looks beyond developing just cool technologies and more into creating solutions that can address important problems to benefit real people.'-- Linda Katehi, Chancellor, University of California at Davis'This superb volume offers a provocative portrait of the exciting future of engineering education.A dramatically new form of engineering education is needed that recognizes this field as a liberal art, as a profession that combines equal parts technical rigor and creative design.The authors challenge the next generation to engineering educators to imagine, think and act in new ways. ' -- Lee S. Shulman, President Emeritus, The Carnegie Foundation for theAdvancementof Teaching and Charles E. Ducommun Professor of Education Emeritus, Stanford University 324 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Recent studies have shown that novel processing and modeling techniques may be used to create patient-specific prostheses, artificial tissues, and other implants using data obtained from magnetic resonance imaging, computed tomography, or other imaging techniques. For example, customized prostheses may be fabricated that possess suitable features, including geometry, size, and weight, for a given medical condition. Many advances have been made in the development of patient-specific implants in the past decade, yet this information is not readily available to scientists and students. Printed Biomaterials: Novel Processing and Modeling Techniques for Medicine and Surgery provides the biomaterials scientist and engineer, as well as advanced undergraduate or graduate students, with a comprehensive discussion of contemporary medical implant research and development. The development of printed biomaterials is multidisciplinary, and includes concepts traditionally associated with engineering, materials science, medicine, and surgery. This text highlights important topics in these core fields in order to provide the fundamentals necessary to comprehend current processing and modeling technologies and to develop new ones. 140 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book attempts to give a discussion of the physics and current and potential applications of the self-focusing of an intense femtosecond laser pulse in a tra- parent medium. Although self-focusing is an old subject of nonlinear optics, the consequence of self-focusing of intense femtosecond laser pulses is totally new and unexpected. Thus, new phenomena are observed, such as long range lam- tation, intensity clamping, white light laser pulse, self-spatial ltering, self-group phase locking, self-pulse compression, clean nonlinear uorescence, and so on. Long range propagation at high intensity, which is seemingly against the law of diffraction, is probably one of the most exciting consequences of this new sub- eld of nonlinear optics. Because the intensity inside the lament core is high, new ways of doing nonlinear optics inside the lament become possible. We call this lamentation nonlinear optics. We shall describe the generation of pulses at other wavelengths in the visible and ultraviolet (UV) starting from the near infrared pump pulse at 800 nm through four-wave-mixing and third harmonic generation, all in gases. Remotely sensing uorescence from the fragments of chemical and biological agents in all forms, gaseous, aerosol or solid, inside the laments in air is demonstrated in the labo- tory. The results will be shown in the last part of the book. Through analyzing the uorescence of gas molecules inside the lament, an unexpected physical process pertaining to the interaction of synchrotron radiation with molecules is observed. 144 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Igniting the Power of Community: The Role of CBOs and NGOs in Global Public Health introduces readers to the pursuit and potential of community-based organizations and nongovernmental organizations to transform global public health. At a time of unprecedented challenges, economic crises, social inequalities, environmental stressors, emerging health threats, these organizations are initiating and driving change, often being the first to call attention to the issues and increasingly forging significant and sustainable solutions.Through concrete examples, success stories, and cautionary tales from experienced practitioners, Igniting the Power of Community demonstrates why understanding the roles of the diverse organizations of this sector is vital to anyone concerned with improving health and public health today. This forward-thinking book explains how citizen sector organizations work, their immediate and long term impact on public health, and the key players and business dynamics involved. With an emphasis on innovative approaches, it provides an 'insiders view' into practical considerations regarding organizational structure, financing, and operations. A sampling of the coverage:The new era of social entrepreneurship and philanthropySustainability in international public health NGOsFront-line perspectives from both well-established and grassroots CBOsFaith-based organizations and public healthNGOs and the military: evolving relationships in conflict and disaster zonesUnderstanding the environmental health movement and its impactProject YEAH: a youth AIDS organizations story.Whether you are involved in clinical care, health research, public health programs, or policy development and implementation, this book provides key insights and skills, and will serve as an invaluable resource in working most effectively with and within these dynamic organizations.body> 432 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally. 312 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Building on the historical analysis of organizations and theories that have influenced their development, Gianfranco Dioguardi provides an insightful exploration of the network enterprise and its evolution from the Medieval guilds to the present innovation clusters of Silicon Valley, the Research Triangle, Route 128, and other regions in the U.S and around the world. Providing in-depth analysis of production systems and the evolution of 'lean manufacturing' principles, Dioguardi integrates history, sociology, management theory, and economics to explore the dynamics of organizations that operate as networks and interact with other firms along the supply chain and in complementary industries. In a technology-enabled environment, the boundaries between products and services and across enterprises become blurred-and create the context for entrepreneurship, innovation, and dissemination of knowledge. Several chapters are devoted to practical concerns of managing the network enterprise, with a particular interest in the ethical and cultural issues. Dioguardi concludes with discussion of the role of the network enterprise in new firm creation and economic growth. 144 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -As our world becomes increasingly interconnected through economic integration, technology, communication, and political transformation, the sphere of the family is a fundamental arena where globalizing processes become realized. For most individuals, family in whatever configuration, still remains the primary arrangement that meets certain social, emotional, and economic needs. It is within families that decisions about work, care, movement, and identity are negotiated, contested, and resolved. Globalization has profound implications for how families assess the choices and challenges that accompany this process. Families are integrated into the global economy through formal and informal work, through production and consumption, and through their relationship with nation-states. Moreover, ever growing communication and information technologies allow families and individuals to have access to others in an unprecedented manner. These relationships are accompanied by new conceptualizations of appropriate lifestyles, identities, and ideologies even among those who may never be able to access them.Despite a general acknowledgement of the complexities and social significance inherent in globalization, most analyses remain top-down, focused on the global economy, corporate strategies, and political streams. This limited perspective on globalization has had profound implications for understanding social life. The impact of globalization on gender ideologies, work-family relationships, conceptualizations of children, youth, and the elderly have been virtually absent in mainstream approaches, creating false impressions that dichotomize globalization as a separate process from the social order. Moreover, most approaches to globalization and social phenomena emphasize the Western experience. These inaccurate assumptions have profound implications for families, and for the globalization process itself. In order to create and implement programs and policies that can harness globalization for the good of mankind, and that could reverse some of the deleterious effects that have affected the world's most vulnerable populations, we need to make the interplay between globalization and families a primary focus. 240 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -There are several reasons to be interested in infectious disease informatics. First, it is of practical significance to understand how the technology revolution has been reshaping infectious disease research and management, as rapid advances in geno- associated technologies have changed the very nature of the questions we can ask. Second, the emerging evidence has confirmed that the application of information technologies in healthcare enhances our ability to deal with infectious diseases. Finally, the implementation of electronic health records has created new and exciting opportunities for secure, reliable and ethically sound clinical decision support and biosurveillance guided by the genomics of pathogens with epidemic potential. This volume addresses the growing need for the critical overview of recent developments in microbial genomics and biomedical informatics relevant to the control of infectious diseases. This field is rapidly expanding, and attracts a wide audience of clinicians, public health professionals, biomedical researchers and computer scientists who are fascinated by the complex puzzle of infectious disease. This book takes a multidisciplinary approach with a calculated move away from the traditional health informatics topics of computerized protocols for antibiotic p- scribing and pathology testing. Instead authors invite you to explore the emerging frontiers of bioinformatics-guided pathogen profiling, the system microbiolo- enabled intelligent design of new drugs and vaccines, and new ways of real-time biosurveillance and hospital infection control. Throughout the book, references are made to different products supplied by public sources and commercial vendors, but this is not an endorsement of these products or vendors. 448 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Chemokine Receptors and NeuroAIDS: Beyond the Co-receptor Function and Links to Other Neuropathologies focuses on unresolved or emerging issues concerning the role of chemokine receptors in neuronal injury and HIV neuropathology, including their ability to regulate fundamental neuronal and glial functions and their role in neurovirulence and neurotoxicity. Although the importance of these molecules in the CNS physiology and pathology is now apparent, these issues are still matter of debate, and further research is required to design effective pharmacological agents that specifically target the brain chemokine system without major side effects.To this end, specific topics have been selected and are reviewed by international experts within the basic science/medical community. This book encourages investigation in the most controversial areas and fosters interaction between clinicians and basic scientists. The book also increases awareness about differences in disease progression among different parts of the world as well as selected patient populations, which may also help identifying novel therapeutic strategies. 428 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Course covers topics in infectious diseases in children and is intended for Pediatric Infectious disease trainees, trainers, and all those who manage children with infections.Each of the chapters in this book is based on a lecture given at the sixth 'Infection and Immunity in Children' course, held at the end of June 2008 at Keble College, Oxford.Thus, it is the sixth book in a series that provides succinct and readable updates on just about every aspect of the discipline of Pediatric Infectious Diseases. 220 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression. 288 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The International Conference of Harmonization (ICH) has worked on har- nizing the stability regulations in the US, Europe, and Japan since the early 1990s. Even though the Stability Guidelines Q1A (R2) was issued over a decade ago, issues surrounding this arena continue to surface as the principles described in the guideline are applied to different technical concentrations. As a result, the stability community has continued to discuss concerns and find ways of harmonizing regulatory requirements, streamlining practices, improving processes in order to bring safe and effective medical supplies to the patients around the world. In 2007, the American Association of Pharmaceutical Scientists (AAPS) Stability Focus Group organized two workshops - the Stability Workshop and the Degradation Mechanism Workshop. These meetings attracted many industry scientists as well as representatives from several regulatory agencies in the world to discuss important topics related to pharmaceutical stability practices. Recognizing the importance of documenting these discussions and with the permission of AAPS, I have worked with speakers to assemble a collection of 30 articles from presentations given at these two meetings, mainly the Stability Workshop. I trust that this book will be beneficial to all of you in providing guidance and up-to-date information for building quality stability programs. v Freedom of our mind is Mother of all inventions. 288 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Discovery of Ribonuclease P and Enzymatic Activity of Its RNA Subunit Sydney Brenner and Francis H. C. Crick had a specific project in mind when they offered Sidney Altman a position in their group in 1969 to conduct postdoctoral research at the Medical Research Council Laboratory of Molecular Biology (LMB) in Cambridge, England. At the time, an intense international competition was on- ing in as many as a dozen labs to determine the three-dimensional structure of tRNA. At the LMB, Aaron Klug was attacking the structure by crystallographic analysis with Brian F. C. Clark providing large amounts of purified phenylalanine tRNA. (Eventually, Aaron announced his empirically determined 3-D structure of yeast phenylalanine tRNA, a structure that is generally common to tRNAs, due in part to several conserved, novel three-way nucleotide interactions. ) Concurrently, Michael Levitt, a Ph. D. student of Francis, was visually scrutinizing the cloverleaf secondary structure of the 14 tRNA sequences known at the time. Levitt was searching for nucleotide covariation in different parts of the molecules that were conserved in the 14 sequences known at the time. He identified a possible covariation of an apparent Watson-Crick pairing type between the residues at position 15 from the 5' end of the tRNA and residue 48. This association implied these parts of the tRNA, namely the D loop containing residue 15 and the 5' end of the T stem-adjoining residue 48, folded on one another in a tertiary structure shared by different tRNAs. 300 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Channing Der and colleagues provide an encyclopedic overview of the Rho GTPases, providing enough detail to make any reader well-versed in the Rho field. Finally, Sofia Merajver's laboratory provides an overview, which details the roles of the Rho proteins in cancer progression. She provides us with the history of the study of the Rho GTPases, their regulatory and effector proteins in cancer and gives us a benchmark of where the field is today. The second section of the book details the current knowledge of the Rho regu- tory proteins in cancer progression: aberrant expression and activation of these proteins leads to dysfunctional Rho signaling and a cancer phenotype. Gary Bokoch's laboratory has provided a detailed overview of the role of Rho guanine dissociation inhibitors (GDIs) in cancer. These molecules are involved in preventing the Rho protein from associating with the inner plasma membrane and exchanging GDP for GTP, and thus becoming active. Next, Tozu Kazasa's labo- tory has worked on the link between heterotrimeric G proteins and Rho activation via the RGS-RhoGEFs. This aspect of Rho activation is particularly interesting in that heterotrimeric G proteins and their associated G-protein-coupled receptors are attractive and attainable therapeutic targets. Dan Billadeau's laboratory has worked extensively on the Vav RhoGEFs, which are potent oncogenes in their own right. 228 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Squamous cell carcinoma of the oral cavity (SCCOC) is one of the most prevalent tumors of the head and neck region. Despite improvements in treatment, the survival of patients with SCCOC has not significantly improved over the past several decades. Most frequently, treatment failure takes the form of local and regional recurrences, but as disease control in these areas improves, SCCOC treatment failures more commonly occur as distant metastasis. The presence of cervical lymph node metastasis is the most reliable adverse prognostic factor in patients with SCCOC, and extracapsular spread (ECS) of cervical lymph nodes metastasis is a particularly reliable predictor of regional and distant recurrence and death from disease. Decisions regarding elective and therapeutic management of cervical lymph node metastases are made mainly on clinical grounds as we cannot always predict cervical lymph node metastasis from the size and extent of invasion of the primary tumors. Therefore the treatment of the neck disease in the management of SCCOC remains controversial. The promise of using biomarker-based treatment decisions has yet to be fully realized due to our poor understanding of the mechanisms of regional and distant metastases of SCCOC. We will summarize the current status of investigations into SCCOC metastases and potential of these studies to impact basic research investigators and clinicians confronting SCCOC in the future. 364 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Breast cancer remains a disease of considerable public health importance worldwide, with over 800,000 new cases diagnosed globally each year. Considerable energy is currently being spent by researchers to further our understanding of this complex disease, however, keeping up with all of the new data is a real challenge given the sheer volume of information that becomes available on a daily basis. The purpose of this book would be to provide a comprehensive review of breast cancer epidemiology, covering the topics of disease burden, etiology, risk factors, prevention, early detection/screening, treatment, and outcomes. The book would be a single comprehensive source of the most recent information on breast cancer epidemiology, and it would serve as a valuable resource for breast cancer researchers across disciplines regardless of what stage of their career they are in. To the knowledge of the editor, no such resource is currently available. 432 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book presents an overview of the outcomes resulting from applying the dynamical systems approach to space mission design, a topic referred to as 'Space Manifold Dynamics' (SMD). It is a natural follow-on to the international workshop 'Novel Spaceways for Scientific and Exploration Missions,' which was held in October 2007 at the Telespazio Fucino Space Centre (Italy) under the auspices of the Space OPS Academy. The benefits and drawbacks of using the Lagrangian points and the associated trajectories for present and future space missions are discussed. The related methods and algorithms are also described in detail. Each topic is presented in articles that were written as far as possible to be self consistent; the use of introductory sections and of extended explanations is included in order to address the different communities potentially interested in SMD: space science, the aerospace industry, manned and unmanned exploration, celestial mechanics, and flight dynamics. 276 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Juvenile Delinquency in Europe and Beyond: Results of the Second International Self-Report Delinquency Studypresents the status of juvenile crime and delinquency and its backgrounds in many of the European Union member states as well as in the United States, Canada, Venezuela and Surinam. The book includes information on key issues in juvenile delinquency such as victimization of young people, alcohol and drug use and its relation to juvenile crime, involvement in youth gangs, immigration, family and school and neighborhood situations. It provides insight into different views on what can be considered juvenile crime; what acts are subsumed in its definition and when we can speak about structural delinquent behavior. These insights are based on self-reported information systematically and simultaneously collected from about 70,000 12-15 year old youths in 28 countries. Until recently, the self-report methodology has not been applied on such a large scale in an international context. The results of this survey provide new and unexpected data about those young people who structurally commit criminal acts, as well as on the frequency of the behavior and the conditions that have an impact on offending.The wealth of descriptions and insights in delinquency of all these countries will be of great interest to scholars, students and practitioners because of the special character of the publication; it is a book of reference to everyone interested in the backgrounds of juvenile delinquency. 452 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -'Piezoelectric-Based Vibration-control Systems: Applications in Micro/Nano Sensors and Actuators' covers: Fundamental concepts in smart (active) materials including piezoelectric and piezoceramics, magnetostrictive, shape-memory materials, and electro/magneto-rheological fluids; Physical principles and constitutive models of piezoelectric materials; Piezoelectric sensors and actuators; Fundamental concepts in mechanical vibration analysis and control with emphasis on distributed-parameters and vibration-control systems; and Recent advances in piezoelectric-based microelectromechanical and nanoelectromechanical systems design and implementation. 517 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins. 328 pp. Englisch.