springer new york feb 2016 (18 results)

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume examines the distinctive and highly problematic ethical questions surrounding conflict archaeology. By bringing together sophisticated analyses and pertinent case studies from around the world it aims to address the problems facing archaeologists working in areas of violent conflict, past and present. Of all the contentious issues within archaeology and heritage, the study of conflict and work within conflict zones are undoubtedly the most highly charged and hotly debated, both within and outside the discipline. Ranging across the conflict zones of the world past and present, this book attempts to raise the level of these often fractious debates by locating them within ethical frameworks. The issues and debates in this book range across a range of ethical models, including deontological, teleological and virtue ethics. The chapters address real-world ethical conundrums that confront archaeologists in a diversity of countries, including Israel/Palestine, Iran, Uruguay, Argentina, Rwanda, Germany and Spain. They all have in common recent, traumatic experiences of war and dictatorship. The chapters provide carefully argued, thought-provoking analyses and examples that will be of real practical use to archaeologists in formulating and addressing ethical dilemmas in a confident and constructive manner. 264 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book comprehensively covers the classification, histopathology, pathogenesis, and molecular diagnosis of vascular tumors and malformations, correlating these with current approaches to clinical management. It offers a new multidisciplinary resource for clinicians, pathologists, molecular diagnosticians, and scientists in the field of vascular medicine and biology, fostering cross-cutting collaboration in clinical practice and research. Fundamental background information on vascular tumors and malformation is provided, while also including the most current information available on pathogenic mechanisms underlying this heterogenous group of disorders and the implications for molecular diagnosis and therapeutic intervention.Written by experts in the field, Vascular Tumors and Developmental Malformations: Pathogenic Mechanisms and Molecular Diagnosis provides the medical and scientific community with an essential, practical resource to guide accurate diagnosis, well-targeted therapies, and informed investigation of specific clinicopathological entities within the spectrum of vascular anomalies. 160 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume describes up-to-date techniques for improved production of secondary metabolites of economic interest using field and laboratory methods. Biotechnology of Plant Secondary Metabolism: Methods and Protocols explores different secondary metabolite classes, whole-plant and cell/organ culture systems, and environmental and genetic transformation-based modulation of biochemical pathways. Special focus is given to cell and tissue specific metabolism, metabolite transport, microRNA-based technology, heterologous systems expression of enzymes and pathways leading to products of interest, as well as applications using both model and non-model plant species. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and cutting-edge, Biotechnology of Plant Secondary Metabolism: Methods and Protocols is a great resource for scientists of interdisciplinary fields--plant science, plant physiology, pharmacy, molecular biology, biochemistry, bioengineering, and forestry--in reaching their goals of producing plant biochemicals in a sustainable and efficient manner, while minimizing impacts to the environment and providing the required quantities of these commodities to industry. 192 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volumeexplores the evolution of bacterial cancer therapy and describes the moderntechniques used in therapy today. The chapters in this book cover a broad rangeof topics such as the development of tumor-targeting Salmonella typhimurium A1-R, a microfluidic device for precise quantification of the interactions betweentumor-targeting bacteria and tumor tissue, non-invasive in vivo imaging ofbacteria-mediated cancer therapy using bio-luminescent bacteria, methods toachieve remote-control of therapeutic gene expression in tumor-targetingbacteria, and cell-cycle decoy of cancer cells resistant to cytotoxic drugs todrug sensitivity by S. typhimurium A1-R. This book concludes witha chapter on the future potential of bacterial therapy of cancer. Written inthe highly successful Methods in Molecular Biology series format,chapters include introductions to their respective topics, lists of thenecessary materials and reagents, step-by-step, readily reproducible laboratoryprotocols, and tips on troubleshooting and avoiding known pitfalls.Thoroughand informative, Bacterial Therapy of Cancer: Methods and Protocolsisa valuable resource for anyone who is interested in cancer and bacterialtherapy. 204 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume presents an overview of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) structure and function. It then continues with methods for the analysis of these pathways including conventional enzymological assays, contemporary mass spectrometric analysis techniques, specialized molecular biological approaches applicable to NRPSs and PKSs, and small molecule analysis tools tailored to this very special class of natural products, and concludes by examining bioinformatics tools for the analysis of these enzymes, pathways, and molecules. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Nonribosomal Peptide and Polyketide Biosynthesis: Methods and Protocols serves as a valuable reference for those experienced in studying NRPS and PKS enzymes, pathways, and natural products as well as a gateway for those just entering the field. 296 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume covers the latest protocols designed to identify and characterize TEs in genomes, ancient or recently inserted. Additionally, this book includes a series of protocols designed to understand how host genomes act to regulate the activity of TEs, from elegant genetic mobilization assays to key biochemical methods. Finally, this book also includes chapters that describe how TEs can be used for biotechnological applications. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Transposons and Retrotransposons: Methods and Protocolsaims to ensure successful results in the further study of this vital field. 448 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume describes prominentmethodologies developed by laboratories that have been leading the field ofquantitative proteomics by mass spectrometry. The procedures for performing theexperiments are described in an easy-to-understand manner with many technicaldetails that usually are not reported in typical research articles. This secondedition of Quantitative Proteomics by Mass Spectrometryprovides a broad perspective of the methodologiesused for quantifying proteins and post-translational modifications in differenttypes of biomedical specimens. Written in the highly successful Methods inMolecular Biology series format, chapters include introductions to theirrespective topics, lists of the necessary materials and reagents, step-by-step,readily reproducible laboratory protocols, and tips on troubleshooting andavoiding known pitfalls.Authoritative and thorough, QuantitativeProteomics by Mass Spectrometry, Second Editionis avaluable resource to help researchersunderstand and learn about thelatest tools used in the study of quantitative proteomics by mass spectrometry. 320 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This updated volume explores a wide variety of clinical applications of PCR such as detecting DNA methylation, detection of viruses and protozoa in infectious diseases, estimation of gene copy number aberrations, primer extension coupled with mass spectroscopy, and high throughput NGS techniques. The application of PCR has shown incredible value in the study of genomics and transcriptomics, not only for discovery but also for routine clinical applications, and it forms the cornerstone of personalized medicine. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and authoritative, Clinical Applications of PCR, Third Edition serves as an ideal guide for researchers aiming to understand the principles behind each application and for their implementation in the laboratory. 204 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The aim of this book is to improve pyrosequencing protocols as well as instrumentation for better clinical use by describing improvements and novel applications of pyrosequencing technology. Divided into five parts, the book's thirty chapters explore advances in pyrosequencing template preparation, pyrosequencing technology innovations, multiplex pyrosequencing based on barcodes, the miniaturization of pyrosequencing equipment, as well as various applications. As part of the Springer Protocols program, chapters contain the kind of detail and practical implementation advice to guarantee successful results in the lab. Comprehensive and thorough, Advances and Clinical Practice in Pyrosequencing serves as a valuable reference for researchers who are engaged in personalized medicine, disease control, and DNA diagnosis in numerous other fields. 424 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume covers a large area, from the description of methodologies for data analysis to the real application. Chapters focus on methodologies for preprocessing of microarray data, a survey of miRNA Data analysis, Cloud-based approaches, application of data mining techniques for data analysis, biclustering to query different datasets, web-based tool to analyze the evolution of miRNA clusters, application of biclustering to mine patterns of co-regulated genes ontologies, microarray and proteomic Data, Gene Regulatory Network Inference, Gene Regulatory Network methods, analysis of Mouse data for metabolomics studies, analysis of microRNA data in Multiple Myeloma, microarray data analysis in Gliobastomas, and microRNA data in Cardiogenesis.Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Microarray Data Analysis: Methods and Applications, Second Edition aims to ensure successful results in the further study of this vital field. 240 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume discusses the latest advancements and technologies used in cancer drug resistance research. Cancer Drug Resistance: Overviews and Methods contains chapters that cover topics such as: studying the mechanics of resistance to DNA damaging therapeutic drugs; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; the role of microRNAs in current pancreatic cancer treatment; and cancer exosomes as mediators of drug resistance or clinical and molecular methods in drug development and the use of bioinformatics in the management of cancer drug resistance data. Written in the highly successful Methods in Molecular Biology series format, chapters include overviews of the main issues in cancer drug resistance and the respective mechanisms, as well as introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cancer Drug Resistance: Overviews and Methods, is a valuable resource to researchers, oncobiologists and clinical oncologists or anyone else who is interested in the study of cancer and its drug resistances. 328 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Thisbook offers eleven coordinated reviews on multi-scalestructure formation in cosmic plasmas in the Universe. Observations and theories of plasma structures are presentedin all relevant astrophysical contexts, from the Earth's magnetosphere through heliospheric and galactic scales to clusters of galaxies and the large scalestructure of the Universe. Basic processes in cosmic plasmas starting fromelectric currents and the helicity conceptgoverning the dynamics of magnetic structures in planet magnetospheres,stellar winds, and relativistic plasma outflows like pulsar wind nebulae andActive Galactic Nuclei jets are covered. Themulti-wavelength view from the radio to gamma-rays with modern high resolutiontelescopes discussed in the book reveals a beautiful and highly informativepicture of both coherent and chaotic plasma structures tightly connected bystrong mutual influence. The authors are all leading scientists in theirfields, making this book an authoritative, up-to-date and enduring contributionto astrophysics. 364 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This title brings to light the discoveries and insights into the lives of many marine species made possible over the last decade by passive acoustic recorders (PAR). Pop-ups, ARF, HARP, EAR, Bprobe, C-POD Atag, and Dtag are the acronyms of some of the many PARs that have changed our understanding of how marine animals live and strive in the ocean. Various types of PARs are used by different investigators in different areas of the world. These recorders have accumulated copious amounts of very important data, unveiling previously unknown information about large marine animals. Temporal, seasonal and spatial distribution patterns have been uncovered for many marine species. There have been many discoveries, new understandings and insights into how these animals live in and utilize the ocean and the importance of acoustics in their lives. Listening Within the Ocean summarizes these important discoveries, providing both a valuable resource for researchers and enjoyable reading for non-professionals interested in marine life. 424 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Receptor and Ion Channel Detection in the Brain provides state-of-the-art and up-to-date methodological information on molecular, neuroanatomical and functional techniques that are currently used to study neurotransmitter receptors and ion channels in the brain. The chapters have been contributed by world-wide recognized neuroscientists who explain in an easy and detailed way well established and tested protocols embracing molecular, cellular, subcellular, anatomical and electrophysiological aspects of the brain. This comprehensive and practical manual is presented in a simple, step-by-step manner for laboratory use, and also offers unambiguous detail and key implementation advice that proves essential for successful results and facilitate choosing the best method for the target proteins under study. This work serves as a useful guide for young researchers and students in training as well as for neurologists and established scientists who wish to extend their repertoire of techniques. 496 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume describes different up-to-date methodological approaches, ranging from physiological assays to imaging and molecular techniques, to study a wide variety of plant responses to environmental cues. Environmental Responses in Plants: Methods and Protocols is divided into four sections: Tropisms, Photoperiodism and Circadian Rhythms, Abiotic Stress Responses, and Plant-Pathogen Interactions. The chapters in these sections include detailed protocols to investigate some of the many key biological processes underlying plant environmental responses, mostly in the model organism Arabidopsis thaliana, but also in Physcomitrella patens and in different crop species such as rice, potato, barley, or tomato. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Environmental Responses in Plants: Methods and Protocols, is a great resource for plant physiologists, biochemists, and cell and molecular scientists interested in this exciting and fast-growing research topic. 404 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is a collection of papers presented at the 9th International Conference of Military Geoscience that was held in 2011. The conference included discussion on a diverse range of geosciences, including military history, military geology, teaching geology from a military prospective, geological influence on the battlefield, and environmental and cultural issues related to management of military lands. Geology and geography have played a significant role in military history, from providing the stone for primitive tools and weapons, to the utilization of terrain in offensive and defensive strategies. Specific to this volume, deserts comprise nearly a third of the Earth's surface and have been the site of numerous battles where the dust, heat, and a lack of food and water have provided challenges to military leaders and warriors. This book examines the role of deserts in past and modern warfare, the problems and challenges in managing military lands in desert regions, and how desert environmental conditions can impact military equipment and personnel. This proceedings volume should be of interest to scholars, professionals, and those interested in military history, warfare, geology, geography, cultural resources, general science, and military operations. 392 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The International Society for Justice Research (ISJR) aims to provide a platform for interdisciplinary justice scholars who are encouraged to present and exchange their ideas. This exchange has yielded a fruitful advance of theoretical and empirically-oriented justice research.This volume substantiates this academic legacy and the research prospects of the ISJR in the field of justice theory and research. Included are themes and topics such as the theory of the justice motive, the mapping of the multifaceted forms of justice (distributive, procedural) and justice in context-bound spheres (e.g. non-humans). It presents a comprehensive 'state of the art' overview in the field of justice research theory and it puts forth an agenda for future interdisciplinary and international justice research. It is worth noting that authors in this proposed volume represent ISJR's leading scholarship. Thus, the compilation of their research within a single framework exposes potential readers to high quality academic work that embodies the past, current and future trends of justice research. 532 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In two volumes, this new edition presents the state of the art in Multiple Criteria Decision Analysis (MCDA). Reflecting the explosive growth in the field seen during the last several years, the editors not only present surveys of the foundations of MCDA, but look as well at many new areas and new applications. Individual chapter authors are among the most prestigious names in MCDA research, and combined their chapters bring the field completely up to date.Part I of the book considers the history and current state of MCDA, with surveys that cover the early history of MCDA and an overview that discusses the 'pre-theoretical' assumptions of MCDA. Part II then presents the foundations of MCDA, with individual chapters that provide a very exhaustive review of preference modeling, along with a chapter devoted to the axiomatic basis of the different models that multiple criteria preferences. Part III looks at outranking methods, with three chapters that consider the ELECTRE methods, PROMETHEE methods, and a look at the rich literature of other outranking methods.Part IV, on Multiattribute Utility and Value Theories (MAUT), presents chapters on the fundamentals of this approach, the very well known UTA methods, the Analytic Hierarchy Process (AHP) and its more recent extension, the Analytic Network Process (ANP), as well as a chapter on MACBETH (Measuring Attractiveness by a Categorical Based Evaluation Technique). Part V looks at Non-Classical MCDA Approaches, with chapters on risk and uncertainty in MCDA, the decision rule approach to MCDA, the fuzzy integral approach, the verbal decision methods, and a tentative assessment of the role of fuzzy sets in decision analysis.Part VI, on Multiobjective Optimization, contains chapters on recent developments of vector and set optimization, the state of the art in continuous multiobjective programming, multiobjective combinatorial optimization, fuzzy multicriteria optimization, a review ofthe field of goal programming, interactive methods for solving multiobjective optimization problems, and relationships between MCDA and evolutionary multiobjective optimization (EMO). Part VII, on Applications, selects some of the most significant areas, including contributions of MCDA in finance, energy planning problems, telecommunication network planning and design, sustainable development, and portfolio analysis. Finally, Part VIII, on MCDM software, presents well known MCDA software packages. 1424 pp. Englisch.