Published by Südwestdeutscher Verlag für Hochschulschriften, 2011
ISBN 10: 3838120523 ISBN 13: 9783838120522
Seller: Lucky's Textbooks, Dallas, TX, U.S.A.
Condition: New.
Published by Südwestdeutscher Verlag für Hochschulschriften, 2011
ISBN 10: 3838120523 ISBN 13: 9783838120522
Seller: PBShop.store US, Wood Dale, IL, U.S.A.
PAP. Condition: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.
Published by Südwestdeutscher Verlag für Hochschulschriften, 2011
ISBN 10: 3838120523 ISBN 13: 9783838120522
Seller: PBShop.store UK, Fairford, GLOS, United Kingdom
PAP. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.
Published by Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG, 2011
ISBN 10: 3838120523 ISBN 13: 9783838120522
Seller: AHA-BUCH GmbH, Einbeck, Germany
Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - While investigating the involvement of REV3, the catalytic subunit of TLS Polymerase zeta (Pol zeta) in the development of chemotherapy resistance, it was found that inhibition of REV3 expression per se suppresses colony formation of cancer cells whereas normal cells were less affected. It was confirmed that inhibition of REV3 in various cancer cell lines leads to a growth inhibition, due to accumulation of persistent DNA damage, subsequently leading to the activation of the ATM-dependent DNA damage response (DDR) cascade. Inhibition of REV3 in p53-proficient cancer cells results in a G1-arrest and senescence. In contrast, the inhibition of REV3 in p53-deficient or p53-knockout cancer cells results in a growth inhibition and a G2/M-arrest whereas a small fraction of the p53-deficient or p53-knockout cancer cells can overcome the G2/M-arrest, which results in mitotic slippage and aneuploidy. It is shown for the first time that inhibition of a TLS Pol confers synthetic sickness/lethality specifically in cancer cells. The inhibition REV3 per se suppresses cancer cell growth whereas normal cells are less affected, thus identifying REV3 as a potential target for a cancer-specific therapy.
Published by Südwestdeutscher Verlag für Hochschulschriften, 2011
ISBN 10: 3838120523 ISBN 13: 9783838120522
Seller: Mispah books, Redhill, SURRE, United Kingdom
Paperback. Condition: Like New. Like New. book.