?-Catenin, TCF, and ICAT: Novel Roles in T Cell Development, Function, and Aging

Hossain Mohammad, Zulfiquer:

ISBN 10: 3838334507 / ISBN 13: 9783838334509

Published by LAP Lambert Academic Publishing, 2010

About this Item

196 Seiten; Zustand geprÃft, Versand werktags innerhalb von 24 Stunden. neuwertig und ungelesen ZA 9105047 Sprache: Englisch Gewicht in Gramm: 295.

Seller Inventory # 22091

Bibliographic Details

• Title: ?-Catenin, TCF, and ICAT: Novel Roles in T Cell Development, Function, and Aging
• Publisher: LAP Lambert Academic Publishing
• Publication Date: 2010
• Language: English
• ISBN 10: 3838334507
• ISBN 13: 9783838334509
• Binding: Taschenbuch
• Condition: Wie neu
• Weight: 295 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

In addition to working together to drive expression of target genes, ?-catenin and TCF often work independently of each other. They both regulate several stages of T cell development, but their mode of action remains poorly understood. To study the specific role of ?-catenin-TCF interactions in T cells, we generated transgenic mice that express ICAT, a naturally occurring inhibitor of ?-catenin-TCF interactions, in the T cell lineage. We found that ?-catenin-TCF interactions are important for thymocyte survival, but not for proliferation or differentiation. Interestingly, thymocyte aging slows down in ICAT-Tg mice, suggesting a role for ?-catenin-TCF interactions in normal thymic involution. We also discovered that ?-catenin-TCF interactions provide survival signals to activated T cells and promote differentiation of activated CD4 T cells into the default Th2 lineage. However, TCF represses Th1 differentiation independently of its interaction with ?-catenin. This study, thus, provides novel insights into the role of ?-catenin and TCF in T cell development, function, and aging, and should of interest to immunologists, developmental biologists, and gerontologists alike.