A scientific and medical revolution has crept up on us. Twenty-one million Americans are affected by 6,000 so-called rare and orphan diseases, many of which are primarily attributable to misspelled genes. And virtually all diseases have a significant hereditary component. Diabetes, heart disease, the common cancers, mental illness, asthma, arthritis, Alzheimer's disease, and more are having their secrets unlocked through DNA. Families that faced common problems, without hope, are now discovering a new world of understanding, treatment, and prevention. You owe it to yourself to learn about your DNA: how it works, what it reveals, and the benefits and limits of this new knowledge.
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Francis S. Collins, M.D., Ph.D., is a pioneer gene hunter. He spent fifteen years as director of the National Human Genome Research Institute, where he led the international Human Genome Project to a successful completion. For his revolutionary contributions to genetic research he was awarded the Presidential Medal of Freedom in 2007, and the National Medal of Science in 2009. He is the Director of the National Institutes of Health.
Starred Review. A medical revolution is upon us and bestselling author Collins (The Language of God), director of the National Institutes of Health, does a fabulous job of explaining its dimensions. Our knowledge of the genetic basis for disease has increased exponentially in recent years, and we are now able to understand and treat diseases at the molecular level with personalized medicine—care based on an individual's genetic makeup. Collins presents cutting-edge science for lay readers who want to take control of their medical lives. In an enjoyable form, he discusses cancer, obesity, aging, racial differences, and a host of other concerns. Most fascinating is the way Collins discusses the medical advances currently in place and those soon to come that are directly attributable to the federal government's Human Genome Project, headed by Collins, and which mapped the entire human genome. Collins is also not shy about taking on large political issues. He points out problems with our current health-care system, discusses stem-cell research, and in a cogent commentary, recommends—with caveats—direct-to-consumer DNA testing. By using case studies throughout, he does a superb job of humanizing a complex scientific and medical subject. Illus. (Jan.)
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