This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.
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From the Reviews of the Previous Volumes
"The authority, originality, and editing of the reviews are first class."
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"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."
-JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
This volume covers structure and function of all major elements associated with transcription.
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