The Centrosome in Cell Replication and Early Development (Volume 49) (Current Topics in Developmental Biology, Volume 49) - Hardcover

Hardcover

ISBN 10: 012153149X ISBN 13: 9780121531492

Publisher: Academic Press, 2000

Synopsis

Centrosomes play an integral role in the growth of cells and the ultimate development of many animals, and sometimes plants. In addition to the normal growth of cells, centrosomes can also play a key role in the spread of cancer and are of increased interest to both the genetics and oncology communities. Volume 49 of Current Topics in Developmental Biology will present all known research surrounding the centrosome, across a variety of systems, will be well referenced, and speculate where the research is headed.

• Discusses centrosomes and cancer, centrosomes and early development, and molecular biology of the centrosome
• Heavily illustrated, with many color figures
• Chapters written by international leaders in the field

About this title

From the Back Cover

Centrosomes and spindle-pole bodies are cellular organelles involved in the control of the organization of cell cytoplasm in eukaryotes. Collectively referred to as microtubule organizing centers, these organelles play a role in gametogenesis, fertilization, cell reproduction, maintenance of cell structure, cell movements, and control of the distribution of important regulatory molecules and membrane-bound organelles. Further, faulty control of centrosome numbers or centrosome components can contribute to diseases such as cancer and could contribute to infertility. The Centrosome in Cell Replication and Early Development presents a historical perspective of the field and reviews the recent explosive progress in our understanding of the molecular composition of centrosomes, the mechanism of microtubule nucleation, and the regulation of centrosome function during cell replication and early development of organisms.

Key Features

• Discusses centrosomes and cancer, centrosomes and early development, and molecular biology of the centrosome
• Heavily illustrated, with many color figures
• Chapters written by international leaders in the field

Review

"There is no book in print that treats the subject of the centrosome as the only focus of its publication. Thus, the arrival of The Centrosome in Cell Replication and Early Development on the bookshelf is most welcome and fills a genuine need. ...The book covers its subject well. The topics have been well thought out, and the contents are quite up-to-date... This book will serve as a very useful reference guide to cell biologists and a rather comprehensive introduction to the topic for cell-biology students, who can find much of the complexity and mysteries, along with the great variety among systems, presented in a single place. There is much here to stimulate the imagination." --Robert Margolis, Institut de Biologie Structurale, France, in NATURE CELL BIOLOGY (October 2001)

"Overall, this is an excellent book that has clear discussions of all facets of the many-sided centrosome...succeeds in both scope and depth..." --CELL (May 2001)

Edition details

• Publisher: Academic Press
• Publication date: 2000
• ISBN 10: 012153149X
• ISBN 13: 9780121531492
• Binding: Hardcover
• Language: English
• Edition number: 1
• Number of pages: 489
• Editor: Palazzo Robert E., Schatten Gerald P.