Signal Transduction - Hardcover

Gomperts, Bastien D.; Kramer, Ljsbrand M.; Tatham, Peter E.R.

Hardcover

ISBN 10: 0122896319 ISBN 13: 9780122896316

Publisher: Academic Press, 2002

Synopsis

Signal Transduction is a well-illustrated, coherent look at cellular signaling processes. Beginning with the basics, it explains how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and then shows how these inputs are integrated and coordinated. The extensive color artwork provides the reader with a clearer comprehension of key topics, and margin notes are incorporated to highlight milestones in the evolution of signal transduction. This book serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields.

• Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine
• Extensive conceptual colour artwork assists with the comprehension of key topics
• Extensive referencing provides an invaluable link to the core and historical literature
• Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms

About this title

Book Description

The essential reference to the heart of cell biology

From the Back Cover

Signal Transduction is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix, etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particulary cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources key observations and experiments that set the scence for recent and current work.

Edition details

• Publisher: Academic Press
• Publication date: 2002
• ISBN 10: 0122896319
• ISBN 13: 9780122896316
• Binding: Hardcover
• Language: English
• Edition number: 1
• Number of pages: 440