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In their new book, Heart Development, Harvey, Rosenthal, and the contributing authors provide a comprehensive and well-balanced guide to this subject in all its current dimensions, from classic embryology to molecular signaling. The book pays appropriate homage to important recent advances that have come from studies of nonmammalian organisms, and several chapters are devoted to detailed analyses of heart development in the fruit fly, zebrafish, chick, and amphibian. The manner in which the technical or biologic advantages of each of these model systems have enhanced our understanding of mammalian cardiogenesis is readily apparent, and these chapters are purposefully and successfully integrated with those that deal specifically with murine and human heart development. Likewise, chapters that focus on the signaling pathways and transcription factors involved in cell fate and differentiation are well integrated with those that focus on morphology. The book is quite complete in scope and includes chapters devoted expressly to the coronary vasculature, the specialized conducting system of the heart, neural-crest-derived cells, the coordination of cell-cycle control with terminal differentiation in cardiac myocytes, and comparison of the molecular signals controlling cardiogenesis with those involved in the formation of skeletal muscles.
The numerous illustrations are remarkably well crafted, even gorgeous. Almost every page includes full-color drawings that clarify the descriptions of complex morphogenetic or molecular events. The attention so obviously devoted by the authors and editors to these explanatory illustrations is esthetically rewarding and will be particularly valuable to readers with little background in developmental biology.
Serious scholars and investigators in the field will want this book because it is the most accessible, authoritative, and complete summary of cardiac development currently available, one that can serve as a reference for themselves, their students, and their laboratory personnel. Clinicians with an interest in congenital heart disease will likewise find this book to be an invaluable resource. Other cardiovascular specialists or generalists may find the level of detail excessive for general reading. However, the sheer beauty of the book, the usefulness of the index, and the clarity of the illustrations should provide both information and pleasure to a broad readership.
Reviewed by R. Sanders Williams, M.D.
Copyright © 1999 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.
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