RNA Modification (Volume 425) (Methods in Enzymology, Volume 425) - Hardcover

Book 76 of 272: ISSN
 
9780123741554: RNA Modification (Volume 425) (Methods in Enzymology, Volume 425)

Synopsis

The presence of modified nucleotides in cellular RNAs has been known for decades and over 100 distinct RNA modifications have been characterized to date. While the exact role of many of these modifications is still unclear, many are highly conserved across evolution and most contribute to the overall fitness of the organism. In recent years, new methods and bioinformatics approaches have been developed for the dissection of modification pathways and functions. These methods intersect a number of related fields, ranging from RNA processing to comparative genomics and systems biology. In addition, many of the techniques described in this volume have broad applicability, particularly in regards to the isolation, characterization, and reconstitution of ribonucleoprotein complexes, expanding the experimental repertoire available to all RNA researchers.

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About the Author

Jonatha Gott works in the Center for RNA Molecular Biology at Case Western Reserve University, Cleveland, Ohio, USA.

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9780323283748: RNA Modification

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ISBN 10:  0323283748 ISBN 13:  9780323283748
Publisher: Academic Press, 2014
Softcover