Basic Principles of Drug Discovery and Development

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9780124115088: Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development explains that identifying a new drug in the modern era is a multifaceted endeavor that requires a multidisciplinary team approach. It also describes enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine that have become critical to the successful development of marketable therapeutics. This book introduces the fundamental principles of drug discovery and development, beginning with an historical overview of drug discovery. It then educates readers about important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable a new scientist to rapidly understand the key fundamentals of drug discovery including pharmacokinetics, toxicology, and intellectual property, to fill knowledge gaps that could lead to communication issues.

  • Clearly explains the complete drug discovery process from obtaining a lead to testing the bioactivity, to producing the drug and protecting the intellectual property
  • Designed for everyone learning about or thinking of entering the drug discovery space (and transitioning from academia to industry or from another industry to pharma)
  • Simply presents and describes how the pharmaceutical industry works

"synopsis" may belong to another edition of this title.

Product Description:

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics.

The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property."

  • Provides a clear explanation of how the pharmaceutical industry works
  • Explains the complete drug discovery process, from lead, to testing bioactivity, production of the drug, and the process of protecting intellectual property
  • Ideal for anyone interested in learning about the drug discovery process and those contemplating careers in the industry
  • Explains the transition process from academia or other industries

From the Back Cover:

The science of drug discovery covers a wide range of disciplines. This reference text explains that identifying a new drug in the modern era is a multifaceted endeavor that requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. It also describes enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine that have become critical to the successful development of marketable therapeutics.

Given the wide range of disciplines and techniques that are required for cutting edge drug discovery research, it is of paramount importance that scientists have both a mastery of their own fields and a fundamental understanding of their collaborator's fields.

Basic Principles of Drug Discovery and Development provides an introduction to the fundamental principles of drug discovery and development, beginning with an historical overview of drug discovery. It then educates readers about important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. The textbook is designed so that upon completion of a one semester course, students will have been provided with a basic understanding of the drug discovery process.

This reference text provides a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor that is drug research. It is designed to enable a new scientist to rapidly understand the key fundamentals of drug discovery including pharmacokinetics, toxicology, intellectual property. As without a clear understanding, these knowledge gaps could lead to communication issues in a new scientist's early career.

The text and related course material is designed for graduate students in chemistry, biology, pharmacology, biochemistry, pharmacology, toxicology, formulations, who are interested in either a career or to understand the discovery and development of new therapeutic agents with an interest in a career in drug discovery research. Also ideally suited for non-scientists who need to understand the pharmaceuticals industry.

"About this title" may belong to another edition of this title.

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Book Description Elsevier Science Publishing Co Inc, United States, 2015. Hardback. Book Condition: New. 226 x 147 mm. Language: English . Brand New Book. Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property. Bookseller Inventory # AA59780124115088

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Book Description Elsevier Science Publishing Co Inc, United States, 2015. Hardback. Book Condition: New. 226 x 147 mm. Language: English . Brand New Book. Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property. Bookseller Inventory # AA59780124115088

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Book Description Elsevier Science Publishing Co Inc. Hardback. Book Condition: new. BRAND NEW, Basic Principles of Drug Discovery and Development, Benjamin Blass, Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property." * Provides a clear explanation of how the pharmaceutical industry works * Explains the complete drug discovery process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual propertyIdeal for anyone interested in learning about the drug discovery process and those contemplating careers in the industry * Explains the transition process from academia or other industries. Bookseller Inventory # B9780124115088

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