Principles of Cellular Engineering: Understanding the Biomolecular Interface

 
9780124156692: Principles of Cellular Engineering: Understanding the Biomolecular Interface

This comprehensive work discusses novel biomolecular surfaces that have been engineered to either control or measure cell function at the atomic, molecular, and cellular levels. Each chapter presents real results, concepts, and expert perspectives of how cells interact with biomolecular surfaces, with particular emphasis on interactions within complex mechanical environments such as in the cardiovascular system. In addition, the book provides detailed coverage of inflammation and cellular immune response as a useful model for how engineering concepts and tools may be effectively applied to complex systems in biomedicine.

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For the first time there's a single resource focused on engineering at a cellular level. This groundbreaking new work presents basic concepts, key experimental results, and expert conclusions about how cells interact with biomolecular surfaces. It highlights situations in which cells interact and adhere with other cells and surfaces in complex mechanical environments, such as the cardiovascular system. Principles of Cellular Engineering explains the applications of state-of-the-art technologies, including new optical microscopy systems, transfected cell systems, animal models, and computer simulations. Chapters carefully describe novel biomolecular surfaces that have been engineered to control and measure cell function. The book also provides thorough discussion of successful applications of engineering concepts in biomedicine, using the cardiovascular and immune systems as examples. Other topics covered include computer simulation of biological processes, adhesion of cells and macromolecules to biomaterial interaces, cell motility, and mechanical signaling.

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