Extracellular Matrix and The Liver: Approach to Gene Therapy - Hardcover

Hardcover

ISBN 10: 012525251X ISBN 13: 9780125252515

Publisher: Academic Press, 2003

Synopsis

Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses
new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy
approaches.

The chapters are divided into six sections as follows:

• Basic Science of Extracellular Matrix
• Cells Responsible for Extracellular Matrix Production
• Activation Mechanism of Hepatic Cells and Signal Transduction
• Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors
• Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases
• New Strategies for the treatment of Liver Cirrhosis

• Discusses the possibility of gene therapy for liver cirrhosis
• Includes information on new aspects of hepatic stellate cells
• Written by top experts in basic science and clinical hepatology

About this title

From the Back Cover

Extracellular Matrix and the Liver is an overview of recent progress in understanding the cellular and molecular basis of liver fibrosis, with a review of prospective targets for therapy.

Cirrhosis of the liver has been believed to be progressive and incurable. However, interferon therapy for HCV-positive chronic hepatitis and/or liver cirrhosis shows dramatic recovery in some cases. This volume addresses the new strategies for the treatment of all kinds of liver cirrhosis.

The chapters are divided into five sections:
* Basic Science of Extracellular Matrix
* Cells Responsible for Extracellular Matrix Production
* Activation Mechanism of Hepatic Stellate Cells and Signal Transduction
* Basic Science for Extracellular Matrix Metabolism Including Enzymes and Their Inhibitors
* Matrix Metalloproteinases and Tissue Inhibitors for Matrix Metalloproteinases
* New Strategies for the Treatment of Liver Cirrhosis

Edition details

• Publisher: Academic Press
• Publication date: 2003
• Language: English
• ISBN 10: 012525251X
• ISBN 13: 9780125252515
• Binding: Hardcover
• Edition number: 1
• Number of pages: 512
• Editor: Okazaki Isao, Ninomiya Yosifumi, Kyuichi Tanikawa, Friedman Scott I.