Items related to Cancer Biology
Synopsis
A thorough yet concise account of cancer biology, this book emphasizes the cellular and molecular mechanisms involved in the transformation of normal into malignant cells, the invasiveness of cancer cells into host tissues, and the metastatic spread of cancer cells in the host organism. It also defines the fundamental pathophysiological changes that occur in tumor tissue and in the host animal or patient. The approach throughout the book is to discuss the historical development of a field, citing the key experimental advances to the present day, and to evaluate the current evidence that best supports or rules out concepts of the molecular and cellular mechanisms regulating cancer cell behavior. For all the areas of fundamental cancer research, an effort has been made to relate basic research findings to the clinical disease states. The book is well illustrated with schematic diagrams and actual research data to demonstrate points made in the text, and there is an extensive, up-to-date bibliography.
The Third Edition includes completely new chapters on genetic alterations in cancer cells, tumor suppresser genes, transcriptional regulation, growth factors and signal transduction mechanisms, cell cycle regulation and apoptosis, gene-targeted therapy for cancer, and cancer prevention. All other chapters have been thoroughly updated.
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About the Author
Raymond W. Ruddon is at Johnson and Johnson.
Review
"Provides a thorough, yet concise review of the cellular and molecular mechanisms involved in the transformation of normal into malignant cells...Clearly written and well illustrated, there is also an extensive, up-to-date bibliography, making the book valuable to basic scientists, physicians, nurses, and students interested in the field."--Anticancer Research
"Provides a thorough, yet concise review of the cellular and molecular mechanisms involved in the transformation of normal into malignant cells...Clearly written and well illustrated, there is also an extensive, up-to-date bibliography, making the book valuable to basic scientists, physicians, nurses, and students interested in the field."--Anticancer Research
"Excellent chapters cover the major topics in cancer biology and include extensive bibilography sections...Overall this is a well crafted book for graduate students and cancer researchers who wish to learn more about the key concepts and pathways involved in the rapidly advancing field of cancer biology."--Doody's
"Cancer Biology is a single-authored volume that contains nine chapters and over 500 pages of primary text. The author writes from a unique perspective, having assembled the first edition of this book in 1981, and he provides a historical perspective that is unusually appropriate, citing the relevant literature and reproducing some of the figures from 'classic' papers, while at the same time covering more contemporary topics with high scholarship. His narrative is exceptionally well written, interesting, and accessible...Overall, this is an extremely valuable volume that will be of great use to both students and established investigators."--David J. McConkey, MD, as reviewed in The Quarterly Review of Biology
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