The transmembrane electrical potential is a critical aspect of the function of all living cells. In neurons, the dynamics of this potential are of particular importance as the basis for cell signaling. Neurodynamix simulates the dynamic properties of neurons at four levels of neuronal organization and makes the topic of bioelectricity more accessible and less intimidating to students. The modeling system provides a means for students to have access to neurophysiological methods and results by carrying out experiments. Such hands-on simulations deepen students' understanding of electrophysiological concepts and heighten their appreciation of the techniques used to study the electrical properties of cells. The models of Neurodynamix simulate physiological experiments and results dynamically; results are displayed as they are being generated by the models. Based on a highly accessible graphics interface, the computer models encourage active exploration of physiological properties through the manipulation of model parameters while the model experiments are in progress. Section I of the text provides overviews of electrical concepts, the properties of ion channels, resting and action potentials, synaptic interactions, and neuronal circuits. Each of these is followed by descriptions of modeling exercises to be carried out with the NeuroDynamix software. Exercises are designed to illustrate the concepts introduced in the text overviews. Section II provides brief descriptions of the six models incorporated into NeuroDynamix and includes glossaries for variables and parameters. Sections III and IV furnish detailed descriptions of mathematical equations for the models.
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Dr. W. Otto Friesen is Professor of Biology at the University of Virginia. His research interests center on the neuronal control of animal locomotion and currently teaches neurophysiology at the undergraduate and graduate levels.
Jonathon A. Friesen is in his final year of undergraduate eduation as a Computer Science major at the College of William and Mary. Currently, he is SysOp of the student-run computer system at the College of William and Mary.
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Paperback. Condition: Very Good. Dust Jacket Condition: No Dustjacket. First Edition. ISBN 0195082826. Trade Paperback. Textbook. First Printing. CD NOT included! Tight sound copy in very good condition with no apparent markings to the book, minor creasing to covers. No Signature. Seller Inventory # 96113580
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Paper Cover. Condition: Good. No Jacket. First Printing. 203 pages; bibliography; illustrated with line drawings, monitor displays. "NeuroDynamix simulates the dynamic properties of neurons at four levels of neuronal organization; the membrane patch, neuronal compartments, individual neurons, and neuronal circuits. .The modeling system has two interdependent components, this text and the accompanying software. Section I of the text provides overviews of electrical concepts, the properties of ion channels, resting and action potentials, synaptic interactions, and neuronal circuits. Each of these is followed by descriptions of modeling exercises to be carried out with the NeuroDynamix software. .Hardware and software requirements: an IBM or compatible computer with 80286*, 80386*, or 8048DX, or better processor with one megabyte of free RAM and a monochrome or color monitor. Requires MS-Windows Version 3.0 or higher, with EGA, VGA, or SVGA graphics. A hard disk drive with at least two megabytes free disk space and a Microsoft-compatible mouse are also required. (*requires math coprocessor)" Book condition: Software pocket seal is unbroken ; cover corners are somewhat bent and curve upward; rear cover is lightly soiled; I count 25 pages that have text underlining, mostly in the first half of the book. Seller Inventory # 0004343
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