This manual and disk, available in IBM PC and Macintosh formats, accompanies Shepherd's Neurobiology, 3/e. It can be used separately even though it is keyed to the textbook. The 17 experiments investigate such areas as the resting membrane potential, action potential, voltage clamp, physiological properties of nerve cells, and synaptic potentials. The program allows students to propagate the action potential, adjust various parameters and observe the effects on nerve cell firing. Students will learn about equilibrium potentials and the effects of changing ion concentrations, as well as passive and active membrane properties. Separate experiments analyze sodium ion and potassium ion currents, the voltage dependence of these currents, and sleep vs. waking in single neurons. Study questions are provided throughout. This ingeniously-designed program will benefit all undergraduate students of neuroscience.
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John Huguenard is Assistant Professor of Neurology at Stanford University. David McCormick is Associate Professor of Neuroscience at Yale University.
"[A] good and enjoyable way of exploring the properties of different ionic currents, and the way they interact and determine the electrical response of neurons."--Electroencephalography and Clinical Neurophysiology
"Extremely easy to learn and use....up-to-date in implementing relatively recent developments in neurobiology...no book can convey the excitement of actually doing an experiment and seeing the activity of a nerve cell appear on a screen."--Barry Connors, Brown University
"Neuroscience is in need of this kind of approach to learning and this first effort is surely a sign of a future trend towards computer simulations on all kinds of topics. As computers and their accessories become more affordable one can envisage a plethora of information appearing on disk or
CD-ROM for students and teachers alike. This disk is therefore paving the way."--Trends in Neurosciences
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