From Development to Degeneration and Regeneration of the Nervous System - Hardcover

Hardcover

ISBN 10: 0195369009 ISBN 13: 9780195369007

Publisher: Oxford University Press, 2008

Synopsis

This book provides current information about the three areas mentioned in the title: Neuronal Migration and Development, Degenerative Brain Diseases, and Neural Plasticity and Regeneration. The chapters about brain development examine the cellular and molecular mechanisms by which neurons are generated from the ventricular zone in the forebrain and migrate to their destinations in the cerebral cortext. This description of cortical development also includes a discussions of the Cajal-Retzius cell. Another chapter provides insight about the development of another forebrain region, the hypothalamus. The remaining chapters of this section examine the clinical relevance of brain development in certain disease states in humans: neural tube defects and the normal and abnormal development of human electroencephalographic recordings during the first year of age.

The second section on degenerative disorders of the brain begins wtih details about the dopaminergic neurons in the substantia niger and their loss in Parkinson's disease. Two subsequent chapters describe changes in brain aging, including changes in the numbers of myelinated axons. Other chapters in this section describe important cellular and molecular changes found in Alzheimer's disease and human epilepsy. Together, these chapters summarize much of our current knowledge about the major molecular and cellular changes found in several degenerative diseases of the brain.

The last section addresses the issues of brain plasticity and regeneration in the adult brain and begins with a chapter on how the brain's own stem cells provide newly generated neurons to the hippocampal dentate gyrus and how these neurons become integrated into neural circuitry. The following two chapters examine some of the neuroplastic changes that take place in motor and sensory cortices of awake behaving primates. The concluding two chapters address the issue of regeneration in the injured spinal cord and the factors that may contribute to its success.

About this title

About the Author

Charles E. Ribak, PhD is in the Department of Anatomy and Neurobiology at UC Irvine.
Carlos Arumbaro de la Hoz, PhD is at the Instituto de Neurobiologia at Universidad Nacional Autonoma de Mexico. Edward G. Jones, PhD, DPhil is Director, Center for Neuroscience at the University of California, Davis. Dr. Jorge A. Larriva Sahd is at the Instituto de Neurobiologia at the Universidad
Nacional Autonoma de Mexico. Larry W. Swanson, PhD is with the Neuroscience Programme at the University of Southern California, Los Angeles CA.

Review

"...a complete account of the evolution of the field that in over 100 years of development transformed the way we envision neuroscience."--Doody's

Edition details

• Publisher: Oxford University Press
• Publication date: 2008
• ISBN 10: 0195369009
• ISBN 13: 9780195369007
• Binding: Hardcover
• Language: English
• Edition number: 1
• Number of pages: 408
• Editor: Charles E. Ribak, Carlos Arámburo De La Hoz, Edward G. Jones, Jorge A. Larriva Sahd, Larry W. Swanson