Direct Phasing in Crystallography: Fundamentals and Applications (International Union of Crystallography Monographs on Crystallography) - Hardcover

Giacovazzo, Carmelo

Hardcover

ISBN 10: 0198500726 ISBN 13: 9780198500728

Publisher: International Union of Crystallography, 1999

Synopsis

Direct methods are, at present, applied to a large variety of cases: X-ray, neutron or electron data; single crystal and powder data; small molecules and macromolecules. While direct methods solved in practice the phase problem for small molecules, their application to macromolecules is recent and still undergoing strong development. The fundamentals of the methods are described: in particular it is shown how the methods can be optimized for powder, neutron or electron data, and how they can be integrated with isomorphous replacement, molecular replacement and anomalous dispersion techniques. Maximum Entropy methods are also described and discussed. Sets of test structures are used to verify, throughout the various chapters, the mathematical techniques there described and to provide practical examples of applications. This book will appeal to a wide variety of readers - offering both a comprehensive description of direct methods in crystallography and an invaluable reference tool. The

About this title

About the Author

Professor Carmelo Giacovazzo, Professor of Mineralogy, Dipartemento Geomineralogico, Universita di Bari, Via Orabona, 4 70125 Bari, Italy. Tel: 0039 80 5442590. Fax: 0039 80 5442591. Email: giacovazzo@area. ba.cnr.it

Review

"Giacovazzo, an expert in the field . . . , offers excellent, up-to-date coverage of a subject central to the rapidly growing field of crystal structure determinations using X-ray-, neutron-, and electron-diffraction methods. Direct phasing . . . was the subject of the 1985 Nobel Prize in Chemistry and is the workhorse of modern structural investigations. This book is the best comprehensive work on the subject. Giacovazzo begins with first principles and presents the various methods and applications of direct phasing in a systematic, rigorous, and thorough manner. . . . There are many figures, a comprehensive bibliography, several appendixes, and a good index. For molecular biologists, materials scientists, structural chemists, and any other investigators using diffraction techniques. Accessible to graduate students, faculty, researchers, and the occasional gifted upper-division undergraduate."--Choice

"Giacovazzo, an expert in the field . . . , offers excellent, up-to-date coverage of a subject central to the rapidly growing field of crystal structure determinations using X-ray-, neutron-, and electron-diffraction methods. Direct phasing . . . was the subject of the 1985 Nobel Prize in Chemistry and is the workhorse of modern structural investigations. This book is the best comprehensive work on the subject. Giacovazzo begins with first principles and presents the various methods and applications of direct phasing in a systematic, rigorous, and thorough manner. . . . There are many figures, a comprehensive bibliography, several appendixes, and a good index. For molecular biologists, materials scientists, structural chemists, and any other investigators using diffraction techniques. Accessible to graduate students, faculty, researchers, and the occasional gifted upper-division undergraduate."--Choice

"This book by Carmelo Giacovazzo is indeed a modern perspective of phasing in crystallography, as its title claims. In many parts of this work the author is asking provocative questions and provides well substantiated answers, while keeping the mathematics in the text to a minimum and deferring complicated derivations to carefully constructed appendices. Details of related theoretical works of the author and other writers are skipped wherever possible. This book is very likely to be appreciated by crystallographers interested in the principles of direct methods of phase determination as well as by those who would also like to see the mathematical material involved." -- Uri Shmueli, Tel Aviv University

Edition details

• Publisher: International Union of Crystallography
• Publication date: 1999
• ISBN 10: 0198500726
• ISBN 13: 9780198500728
• Binding: Hardcover
• Language: English
• Edition number: 1
• Number of pages: 792