Radical-Mediated Protein Oxidation: From Chemistry to Medicine (Oxford Science Publications) - Hardcover

Davies, Michael J.; Dean, Roger T.

Hardcover

ISBN 10: 0198500971 ISBN 13: 9780198500971

Publisher: Oxford University Press, 1998

Synopsis

Radicals--short lived, reactive molecules--are thought to play a major role in many oxidative processes within cells and to have implications in several human diseases, carcinogenesis, and aging. This unique and comprehensive volume brings together up-to-date information on the oxidation of amino acids, peptides, and proteins by free radicals and discusses the roles of such processes in biological systems. Topics include: the chemistry of amino acid and protein oxidation; the biochemical consequences of these reactions; the role of protein oxidation in normal physiology; the potential importance of protein oxidation in human health, including aging, heart disease, cancer, inflammation, and neurodegenerative diseases; and the possible prevention of disease processes by antioxidants and other protective strategies. Drawing on the latest research across a range of disciplines, this book will be important reading for researchers and graduate and postdoctoral students in the fields of radical biochemistry, physiology, and pathology.

About this title

About the Author

Professor Roger T. Dean, Director, The Heart Research Institute Ltd, 145-147 Missenden Road, Camperdown, Sydney, New South Wales 2050, Australia. Tel: 0061 2 550 3560. Fax: 0061 2 550 3302. Email: r.dean@hri.edu.au

Dr Michael Davies at the same address

Review

"True to its title, this book provides an excellent and broad overview of recent advances in radical-dependent oxidation of proteins . . . Its breadth of coverage and extensive (bordering on comprehensive) citation of the literature . . . makes this a definitive source for experts in the field. The lucid presentation will be similarly attractive to students and professionals with little knowledge of this topic. Valuable tables containing information such as radical mechanisms and products, reaction rate constants, and oxidized amino acids in human tissue have been created to integrate and summarize the salient features of numerous investigations. Most importantly, the authors do not merely compile the results and conclusions of others; instead they provide extensive commentary and critical evaluation of their subjects. This unusually well-written monograph should now be considered the primer for studies on protein oxidation."--The Quarterly Review of Biology

Edition details

• Publisher: Oxford University Press
• Publication date: 1998
• ISBN 10: 0198500971
• ISBN 13: 9780198500971
• Binding: Hardcover
• Language: English
• Edition number: 1
• Number of pages: 456