This book focuses on the discovery of a common genetic basis for a group of inherited neurological disorders, including Huntington's Disease, spino-bulbar atrophy and a series of hereditary ataxias. This shared molecular background and other similarities have led to the development of theoretical models for the pathogenesis of these diseases. It is now also clear that the mechanisms involved are likely to be of more general relevance, outside of this particular group of disorders, with implications for other neurodegenerative processes such as those involved in Alzheimer's, Parkinson's and Prion diseases. The book is an edited and updated compilation evolving from a Royal Society discussion meeting.
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"...this book is a timely assimilation of a large body of work, and it remains the most comprehensive and up-to-date overview of the field at the molecular and cellular level. Besides being an invaluable reference source, it will continue to stimulate scientific interest and involvement in understanding the consequences of polyglutamine expansion in disease." -Trends in Genetics, Vol. 17 No.10, 2001
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