Principles of Nuclear Magnetic Resonance Microscopy - Hardcover

Callaghan, Paul

Hardcover

ISBN 10: 0198539444 ISBN 13: 9780198539445

Publisher: Oxford University Press, 1991

Synopsis

Nuclear magnetic resonance is best known for its spectacular utility in medical tomography. However, the method has potential applications in biology, materials science, and chemical physics, some of which are now being realized as laboratory NMR spectrometers are adapted to enable small scale imaging. NMR microscopy has available a rich variety of contrast including molecular specificity and sensitivity to molecular dynamics. In NMR imaging, the signal is acquired in k-space, a dimension which bears a Fourier relationship with the positions of nuclear spins. A dynamic analogue of k-space imaging is the Pulsed Gradient Spin Echo (PGSE) experiment in which the signal is acquired in q-space, conjugate to the distances moved by the spins over a well-defined time interval. Q-space microscopy provides images of the nuclear self-correlation function with a resolution some two orders of magnitude better than is possible in imaging the nuclear density. As well as revealing the spectrum of molecular motion, PGSE NMR can be used to study morphology in porous systems through the influence of motional boundaries. This book explores principles and common themes underlying these two variants of NMR Microscopy, providing many examples of their use. The methods discussed here are of importance in fundamental biological and physical research, as well as having applications in a wide variety of industries, including those concerned with petrochemicals, polymers, biotechnology, food processing, and natural product processing.

About this title

About the Author

Paul T. Callaghan is at Massey University, Palmerston North.

Review

"By any standards this book is not a 'good read' but a 'good buy' too, and it is clear that it is destined to become a classic of its kind. It is written by an outstandingly able practicing scientist who has incorporated into the text much of that balanced insight which can only be gained by direct experience of the experimental difficulties of the area; that that same scientist has also shared his own sense of excitement, further enhances what would anyway be a wonderful text. . . . Clearly destined to become an NMR classic. I recommend this text without reservation." --The Times Higher Education Supplement

"This book is a joy to read. . . . Clearly, all practitioners of NMR, either 'imaging' or 'spectroscopic,' will be enriched by this book. . . . It is not only the senior experts who will gain; any graduate student or postdoctoral fellow who has a serious commitment to NMR should consider purchasing a personal copy, since they will need to know the entire contents of this book." --Proceedings RMS

"The text is well-written and thoroughly referenced, with 751 literature citations. It is also well-illustrated with many figures and microscopy images, including four pages of full color images....the text will help bridge the physics gap between solution-state NMR and NMR microscopy. The text would be an excellent addition to the library of any scientist interested in modern NMR experiments. The book could be used very nicely as a text book in a graduate course on NMR microscopy. As the technique of NMR microscopy becomes more common, this book will be useful to an increasing number of a wide variety of scientists." --Journal of Medicinal Chemistry

"Excellent. Callaghan is a major contributor in the area of NMR microscopy. . . . he places the field in its historical context and and systematically develops the principles with keen insight. The result is a rigorous and indeed delightful treatment of NMR microscopy from introductory theory to the latest developments in techniques and instrumentation. It is hard to overemphasize the importance of this book to students and research scientists who are interested in NMR imaging, in NMR studies of diffusion and flow and, especially, in the issues where these areas overlap. There is simply nothing like it for this audience!" --American Scientist

"An excellent book....I expect that the book's largest audience will be researchers with some graduate training in physics, chemistry, or engineering....Well written and authoritative so that readers in other disciplines who do not have a strong mathematics background may still find it rewarding....I would recommend this book to anyone who has a sufficient physical science background to handle the fairly rigorous treatment of the material in the book. It is well written with an extensive bibiliography at the end of each chapter..." --Journal of Magnetic Resonance

Edition details

• Publisher: Oxford University Press
• Publication date: 1991
• Language: English
• ISBN 10: 0198539444
• ISBN 13: 9780198539445
• Binding: Hardcover
• Number of pages: 510