Guidebook to the Small GTPases (Sambrook & Tooze Guidebook Series) - Softcover

Softcover

ISBN 10: 0198599447 ISBN 13: 9780198599449

Publisher: Sambrook and Tooze Publications, 1996

Synopsis

In the last few years, the functional divergence of GTPases has attracted the attention of many researchers in structural biology, cell biology, cell growth and differentiation and developmental biology. Numerous studies have contributed important data on the biochemical features, intracellular localization, and functions of these proteins. This book is a summation of the information compiled so far on this family of proteins. An opening section introduces the different subfamilies and the structural features of their various members. The following chapters focus on the individual GTPases, their regulatory components and effector proteins. Intended to serve as an easy-to-use reference, this guidebook will be valued equally by experienced researchers and investigators beginning work in this expanding field.

About this title

About the Author

Marino Zerial is at European Molecular Biology Laboratory, Heidelberg. Lukas A. Huber is at University of Geneva.

From the Back Cover

During the last few years there has been growing interest in the large family of GTPases structurally related to protooncogene product p21 ras. These proteins share structural similarities but are involved in a wide spectrum of biological functions. While members of the ras subfamily regulate cell growth, rho proteins are implicated in the control of cytoskeletal organization in mammalian cells or in bud formation in yeast. Members of the ARF/SAR family are postulated to control vesicle budding, whereas Ypt1/Sec4/rab proteins are thought to regulate vesicle targeting and/or fusion. Owing to their functional divergence, the small GTPases have attracted the attention of many investigators in the fields of structural biology, cell biology, cell growth and differentiation, and developmental biology. Numerous studies have contributed important data on the biochemical features, the intracellular localization, and in some cases the function of these proteins. This book contains entries on almost 150 GTPases which have been identified so far, and the search has not yet been exhausted. This large repertoire of information is gathered together in an easy to consult format. This book is meant to provide a catalogue of the information currently at hand to established scientists in the field, as well as to introduce more investigators to their proteins of interest.

Edition details

• Publisher: Sambrook and Tooze Publications
• Publication date: 1996
• Language: English
• ISBN 10: 0198599447
• ISBN 13: 9780198599449
• Binding: Paperback
• Edition number: 1
• Number of pages: 496
• Editor: Zerial Marino, Huber Lukas A.