Synopsis
Recent developments have revealed that proteins can undergo a diverse range of modifications by lipids which can dramatically effect their structural and functional properties. These modifications include acylation, isoprenylation, and the attachment of glycolipid. Written by acknowledged experts in the field, this unique guide describes the latest biochemical, cell biological, and molecular biological techniques being used in this rapidly expanding area. The book discusses lipid modifications of proteins which play important roles in cellular signalling, protein targeting and cellular growth and differentiation. Detailed protocols are provided for all the key techniques, and the relevant background material is included. The book will be an essential manual for a wide range of scientists studying the modification of protein by lipids, including membrane and protein biochemists, cell biologists, immunologists, bacteriologists, parasitologists, and virologists.
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About the Author
A. J. Turner, Professor of Biochemistry, both at the Department of Biochemistry and Molecular Biology, University of Leeds.
Review
'This book is a comprehensive and authoritative collection of the methods that have been employed to detect and characterize these particular lipid modifications. The editors are to be commended for collecting chapters from undoubted leaders in each respective field ... the wealth of
information ... is accurate and clearly laid out, and this book represents a useful addition to the 'Practical Approach' series.'
C.M. Newman, NIMR, London, Trends in Cell Biology, April 1993, Volume 3, Number 4
'The book is packed with technical details in the now familiar style of the Practical Approach series. It is an excellent and lucid volume with contributions from many of the foremost researchers in the field of lipid modifications, and is clearly intended as a companion in the research
laboratory. Since there are no comprehensive tests on lipid-associated proteins, this book will also have a place as a reference volume on the bookshleves of graduate students and lecturers in many biochemistry and cell biology departments.'
Petr Robinson, Biochemical Education 21(3) 1993
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