Providing a wealth of practical information relating to this area of intense research in cell biology, this comprehensive volume describes the methods essential to identifying and characterizing the the molecules that mediate cellular interactions in a variety of systems. The type of communication between a cell and its immediate environment is closely related to the phenotype of that cell and the structure and function of the tissues and organs in which the cell resides. This detailed approach to cell-cell interactions includes methods for preparing relevant probes, analyzing adhesive and junctional interactions in multicellular organizations, determining which structural features of a relevant molecule are functionally important, and for assaying the consequences of cell-cell interactions in cell culture. Since the methods have applications in many related areas, this book will be invaluable to a wide range of biological scientists and students wishing to investigate the mechanisms and consequences of cellular interactions in their system of choice.
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Bruce R. Stevenson, Department of Anatomy and Cell Biology, University of Alberta. Warren J. Gallin, Department of Zoology, University of Alberta. David L. Paul, Department of Anatomy and Cell Biology, Harvard Medical School.
'an important but often methodologically challenging area of cell biology ... goes a long way towards demystifying the methods involved in studying cell-cell interactions in various contexts ... almost uniformly clearly written ... this book would be very useful to any newcomer to the field of
cell-cell interactions ... a rich resource in introducing the reader to the relevant literature ... it provides an excellent start towards thoughtful and successful scientific investigation of cell-cell interactions'
Anne Hermanowski-Vosatka, The Rockefeller University, New York, Trends in Cell Biology, Vol. 3, August 1993
'There is a lot of valuable iinformation in this particular volume and it will certainly be of use to scientists practising in this field.'
Cell Biology International, Vol. 17, No. 10, 1993
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