Sequence data--either lists of nucleotides or of amino acids--are now easily gathered using automated equipment; the real effort is involved in interpreting the data to produce predictions of protein structure or function. With the advent of worldwide computer networks, a plethora of software is now available for sequence analysis. This book describes the techniques for computer analysis of sequence data, with the emphasis on general issues rather than specific algorithms. Unlike many books on these topics, which focus on the "how-to" aspects of software packages, this one places more emphasis on the science behind the packages and on interpretation of the results.
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In recent years, the volume of nucleic acid and protein sequence generated by researchers has become a flood. Sequence databases have proliferated and good software for sequence analysis has become an absolute necessity. DNA and Protein Sequence Analysis: A Practical Approach provides clear and reasoned practical guidance in the analysis of sequence data and identifies the many pitfalls of interpreting data. The book begins with an overview of molecular biology databases and how to use them. The rest of the book is devoted to a critical appraisal of the software for sequence analysis, what software is available, and how to use it. DNA and Protein Sequence Analysis: A Practical Approach is an essential manual for all researchers in molecular biology and a valuable guide for advanced undergraduates. It will also be indispensable to computer scientists interested in bioinformatics.
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