HIV: A Practical ApproachVolume 2: Biochemistry, Molecular Biology, and Drug Discovery (Practical Approach Series) - Softcover

 
9780199634989: HIV: A Practical ApproachVolume 2: Biochemistry, Molecular Biology, and Drug Discovery (Practical Approach Series)

Synopsis

HIV Volume 2 explores the biochemistry and molecular biology of HIV. Methods for cloning and expressing most of the viral proteins are described as well as assays for studying enzyme function in vitro. It also includes a section on recent approaches to drug discovery.

Contents: The HIV life cycle; Reverse transcriptase; Ribonulease H; Integrase; Protease; Expression of gag, envelope and other HIV antigens using Bacculovirus; Envelope expression and purification; HIV envelope glyocoprotein/CD4 interactions - studies using recombinant vaccinia virus vectors; RNA binding assays for the regulatory proteins tat and rev; Cellular and cell-free assays for tat; Cellular assays for rev; DNA binding proteins interacting with the viral LTR; Nef; Vpu; Vif; Cellular assays for antiviral drugs; Inhibition of HIV by ribozymes and antisense oligonucleotides; Gene therapy approaches to the inhibition of HIV

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About the Author

J. Karn is at MRC Laboratory of Molecular Biology, Cambridge.

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Other Popular Editions of the Same Title

9780199634996: HIV: A Practical ApproachVolume 2: Biochemistry, Molecular Biology, and Drug Discovery (The ^APractical Approach Series)

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ISBN 10:  0199634998 ISBN 13:  9780199634996
Publisher: Oxford University Press, 1995
Hardcover