Items related to Encyclopaedia Medica (Volume 4)
This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1900. Excerpt: ... of urine), and extraction from the washed precipitate with acid alcohol, although it serves admirably for the detection of haematoporphyrin in normal and ordinary morbid urines, does not usually give good results in these cases. Salkowski's method of precipitation with equal volumes of 10 per cent solution of barium chloride and baryta water is certain in its action, but has the disadvantage that the acid alcoholic extract obtained from the precipitate contains the other abnormal pigments. Nebelthau succeeded in precipitating the haematoporphyrin by adding glacial acetic acid to the urine (5 c.c. acid to 100 c.c.) and allowing it to stand for 24-40 hours. Of the processes which are at work in the production of haematoporphyrinuria, we know very little as yet. Stokvis found that when sulphonal was administered to rabbits haematoporphyrin appeared in their urine. Kast and Weiss were not convinced that the pigment excreted under these circumstances was really of this nature, but Stokvis's observation has recently been confirmed by Otto Neubauer. Stokvis also found submucous haemorrhages in the stomach of rabbits poisoned with sulphonal, which gave the spectrum of acid haematoporphyrin, and he was inclined to attribute the haematoporphyrinuria to the action of the gastric juice aided by sulphonal upon the blood so extravasated. However, the records of post-mortem examinations in fatal cases of this condition lend little support to this theory, for although such haemorrhagic areas have sometimes been found, their presence is by no means constant. Blood counts made in a number of cases have failed to show any very conspicuous or progressive diminution of red corpuscles in association with the haematoporphyrinuria, and the evidence available points rather to a p...
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- PublisherGeneral Books LLC
- Publication date2012
- ISBN 10 0217945570
- ISBN 13 9780217945578
- BindingPaperback
- Number of pages332
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