A comprehensive survey of a rapidly expanding field of combinatorial optimization, mathematically oriented but offering biological explanations when required.
From one cell to another, from one individual to another, and from one species to another, the content of DNA molecules is often similar. The organization of these molecules, however, differs dramatically, and the mutations that affect this organization are known as genome rearrangements. Combinatorial methods are used to reconstruct putative...
Guillaume Fertin is Professor of Computer Science at the University of Nantes.
Anthony Labarre received a PhD in Mathematics and Computer Science from the Université libre de Bruxelles.
Irena Rusu is Professor of Computer Science at the University of Nantes.
Eric Tannier is a Researcher at the INRIA, in the Laboratory of Biometrics and Evolutionary Biology of the University of Lyon.
Stéphane Vialette is a Researcher in the Gaspard-Monge Institute of...
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"This book will be a defining book for the field of genome rearrangement and is destined to become a classic as soon as it hits the bookshelves. The authors have done an excellent job in presenting one of the most technically challenging areas of computational biology in an easily understood manner. Dobzhansky and Sturtevant would not be disappointed."--Pavel Pevzner, Ronald R. Taylor Chair of Computer Science, Director, Interdisciplinary Bioinformatics...
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