Evolution of Translational Omics: Lessons Learned and the Path Forward - Softcover

Institute Of Medicine; Board On Health Sciences Policy; Board On Health Care Services; Committee On The Review Of Omics-Based Tests For Predicting Patient Outcomes In Clinical Trials

Softcover

ISBN 10: 0309224187 ISBN 13: 9780309224185

Publisher: National Academies Press, 2012

Synopsis

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Edition details

• Publisher: National Academies Press
• Publication date: 2012
• Language: English
• ISBN 10: 0309224187
• ISBN 13: 9780309224185
• Binding: Paperback
• Number of pages: 354
• Editor: Omenn Gilbert S., Nass Sharly J., Micheel Christine M.