Randomised Response-Adaptive Designs in Clinical Trials (Monographs on Statistics and Applied Probability, 130) - Softcover

Atkinson, Anthony C; Biswas, Atanu

Softcover

ISBN 10: 0367378973 ISBN 13: 9780367378974

Publisher: Chapman and Hall/CRC, 2019

Synopsis

Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training.

After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.

About this title

About the Author

Anthony C. Atkinson is an Emeritus Professor of Statistics at the London School of Economics and Political Science.

Atanu Biswas is a professor in the Applied Statistics Unit at the Indian Statistical Institute, Kolkata.

Edition details

• Publisher: Chapman and Hall/CRC
• Publication date: 2019
• Language: English
• ISBN 10: 0367378973
• ISBN 13: 9780367378974
• Binding: Paperback
• Edition number: 1
• Number of pages: 340