On The Functions Of The Sympathetic System Of Nerves: As A Physiological Basis For A Rational System Of Therapeutics by Edward Meryon. The treatise investigates the anatomy and physiology of the sympathetic system, arguing that every ganglion houses three functional elements: motor nerves, sensory nerves, and Remak (grey) fibres. It maps connections between sympathetic ganglia and cranial, spinal, and facial nerves, and notes the interchanges with spinal nerves that position ganglia near the cord. Based on experiments summarized from Bernard, Schiff, Ogle, and others, the author shows that cutting sympathetic fibers raises tissue heat and capillary dilation, while stimulating or restoring Remak and sensory fibers modulates secretion. He distinguishes that motor fibers to glands drive secretion via vascular and epithelial interactions, while sensory fibers convey tissue vitality. The second part outlines a rational therapeutics: medicines can emulate or oppose sympathetic actions by targeting the three fibre types, to regulate circulation and glandular function. The work concludes with explicit pharmacologic guidance and a program for a rational, science-based therapeutics.
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