The Control Of Hunger In Health And Disease by Anton Julius Carlson offers a comprehensive examination of hunger and appetite across biological scales, from unicellular organisms to humans. Carlson synthesizes laboratory experiments conducted at the Hull Physiological Laboratory of the University of Chicago during 1912–1916, detailing the physiological basis of hunger, satiety, and appetite, and their modulation by nervous, chemical, and reflex mechanisms. The work traces hunger's biological significance in unicellular and plant life, surveys historical theories (gastric vs central origins), and documents methods for studying the stomach's empty-state contractions in humans and animals (gastric fistulas, balloons, X-ray). It then develops a unified framework: hunger is driven by gastric contractions, with central nervous and peripheral reflexes acting as modulators. The book also explores hunger in disease, starvation, diabetes, gastritis, and other conditions, and discusses the differing roles of appetite vs hunger, taste, memory, gastric juice secretion, and bitters. It positions hunger control as a practical clinical target and calls for clinic-laboratory collaboration to advance rational therapeutics.
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