Items related to DNA Repair and Recombination

DNA Repair and Recombination - Hardcover

Lindahl, T R; Lindahl

 
9780412640407: DNA Repair and Recombination

Synopsis

Genomic instability is a major threat to living organisms. To counteract the damaging effects posed by endogenous and environmental agents, such as chemicals or radiation, micro-organisms devote several percent of their genome to encode proteins that function in the repair and recombination of DNA. For many years, a relatively small group of scientists have carefully delineated the molecular mechanisms of these repair processes, using the simplest model systems available, namely Escherichia coli and Saccharomyces cerevisiae. These studies, which until recently had only moderate impact outside of the field, now provide the cornerstone for exciting new research into analogous processes in human cells. The reason for this is the revelation that the biochemical pathways for the accurate replication, repair and recombination of DNA have been conserved through evolution.

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From the Back Cover

In this book, which was generated from a Royal Society discussion meeting, leading international researchers provide a current and authoritative account of all aspects of DNA repair and recombination, from bacteria to humans. It is a timely volume, particularly in view of the revelation that the biochemical pathways of repair and recombination in prokaryotes and lower eukaryotes have been conserved in human cells. There is now much exciting research into understanding the molecular mechanisms of repair and recombination in higher eukaryotes.

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