Protein Dynamics: Experimental and Computational Approaches (Foundations and Frontiers in Enzymology) - Softcover

Softcover

ISBN 10: 0443300429 ISBN 13: 9780443300424

Publisher: Academic Press, 2026

Synopsis

Protein Dynamics: Experimental and Computational Approaches investigates protein biology from a biophysical standpoint. The book covers a wide range of topics, including functional protein dynamics, intrinsically disordered proteins, protein folding, misfolding and aggregation, and membrane protein-protein communication. Protein allosteric conformational changes caused by drug binding and disease-associated mutations are also featured, alongside protein dynamics in the context of computer-based drug design. Biophysical techniques for investigating protein structure-dynamics-function relationships across these topics are explored, considering the latest experimental and computational approaches in the field. This book is an ideal reference for researchers in working in biophysics, biochemistry, and related areas.

• Covers a broad range of biophysical techniques to study protein dynamics
• Investigates an array of different proteins, including receptors, transporters and enzymes
• Considers future directions in the field
• Features explanation of key concepts and end-of-chapter questions to aid understanding

About this title

About the Authors

Ana-Nicoleta Bondar is a full professor of physics at the Faculty of Physics, University of Bucharest, Romania, and currently a visiting professor at the Forschungszentrum Jülich, Institute for Computational Biomedicine, Germany. Prior to this, she led the theoretical molecular biophysics group at the Freie Universität Berlin, Department of Physics. Dr. Bondar’s research is focused on methodological developments and applications for membrane proteins.

Durba Sengupta is Principle Scientist and Assistant Professor at the Physical Chemistry Division
CSIR-National Chemical Laboratory, Pune, India. The main objective of Dr Sengupta’s research group is to understand self organisation and self-assembly in complex bio-systems, using the tools of physical chemistry. The current focus of her research is membrane biology and understanding the structure, dynamics and functions of proteins, lipids, sugars and sterols within the membrane.

From the Back Cover

Protein Dynamics: Experimental and Computational Approaches investigates protein biology from a biophysical standpoint. The book covers a wide range of topics including functional protein dynamics, intrinsically disordered proteins, protein folding, misfolding and aggregation, and membrane protein-protein communication. Protein allosteric conformational changes caused by drug binding and disease-associated mutations is also featured, alongside protein dynamics in the context of computer-based drug design. Biophysical techniques for investigating protein structure-dynamics-function relationships across these topics are explored, considering the latest experimental and computational approaches in the field. This book is an ideal reference for researchers in working in biophysics, biochemistry, and related areas.

Edition details

• Publisher: Academic Press
• Publication date: 2026
• Language: English
• ISBN 10: 0443300429
• ISBN 13: 9780443300424
• Binding: Paperback
• Edition number: 1
• Number of pages: 548
• Editor: Bondar Ana-Nicoleta, Sengupta Durba