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Design and Optimization in Organic Synthesis (Volume 8) (Data Handling in Science and Technology, Volume 8) - Hardcover

 
9780444892010: Design and Optimization in Organic Synthesis (Volume 8) (Data Handling in Science and Technology, Volume 8)

Synopsis

This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experimental conditions and for systematic studies of entire reaction systems (substrates, reagent(s) and solvents). The methodology is based on multivariate statistical techniques.

The following topics are treated in depth: classical two-level designs for screening experiments, gradient methods (steepest ascent, simplex methods) as well as response surface techniques for optimization, principal components analysis and PLS modelling.

The book is intended as a hands-on text for chemists and engineers engaged in developing synthetic methods in industrial research, e.g. in fine chemicals and pharmaceuticals production, as well as for advanced undergraduate students, graduate students, and researchers in an academic environment.

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Book Description

A revised and updated second edition to the only book on Design and Optimization in Organic Synthesis

Review

...a book that is excellent from both the pedagogic and scientific standpoints. ...worthwhile reading for the organic chemist...
Angewandte Chemie
I commend Professor Carlson's book to the union of those who are excited by synthetic organic chemistry and by the design of experiments.
Journal of Chemometrics

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9780444515278: Design and Optimization in Organic Synthesis: Second Revised and Enlarged Edition (Volume 24) (Data Handling in Science and Technology, Volume 24)

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ISBN 10:  0444515275 ISBN 13:  9780444515278
Publisher: Elsevier Science, 2005
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Carlson, R.
Published by Elsevier Science Ltd, 2000
ISBN 10: 044489201X ISBN 13: 9780444892010
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Carlson, R.
Published by Elsevier Science, 1991
ISBN 10: 044489201X ISBN 13: 9780444892010
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Carlson, Rolf
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ISBN 10: 044489201X ISBN 13: 9780444892010
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Carlson, R.
Published by Elsevier Science, 1991
ISBN 10: 044489201X ISBN 13: 9780444892010
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