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This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experimental conditions and for systematic studies of entire reaction systems (substrates, reagent(s) and solvents). The methodology is based on multivariate statistical techniques.
The following topics are treated in depth: classical two-level designs for screening experiments, gradient methods (steepest ascent, simplex methods) as well as response surface techniques for optimization, principal components analysis and PLS modelling.
The book is intended as a hands-on text for chemists and engineers engaged in developing synthetic methods in industrial research, e.g. in fine chemicals and pharmaceuticals production, as well as for advanced undergraduate students, graduate students, and researchers in an academic environment.
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A revised and updated second edition to the only book on Design and Optimization in Organic SynthesisReview:
...a book that is excellent from both the pedagogic and scientific standpoints. ...worthwhile reading for the organic chemist...
I commend Professor Carlson's book to the union of those who are excited by synthetic organic chemistry and by the design of experiments.
Journal of Chemometrics
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