The Synthetic Organic Chemist's Companion - Softcover

Pirrung, Michael C.

Softcover

ISBN 10: 0470107073 ISBN 13: 9780470107072

Publisher: Wiley-Interscience, 2007

Synopsis

The Organic Chemists' Companion provides a practical, hands-on resource for students and practitioners of organic synthesis. It presents the fundamentals and guides the reader through the entire process of organic synthesis. It includes basic instructions on everything from on handling reagents, gases, and solvents to conducting and working up/purifying reactions as well as applying analytical techniques to identify the reaction product.

• Packed with data and practical tips and organized for quick reference
• Includes guidelines for literature searches to help readers find additional information
• Features colour photos, drawings, charts, graphs, and tables to complement the information
• Includes real-life examples showing how to apply the information.

About this title

From the Back Cover

A practical, hands-on guide that belongs in every organic chemistry lab

A unique reference that consolidates essential information in a practical, user-friendly format, The Synthetic Organic Chemist's Companion provides a detailed description

of how to perform synthetic reactions in real-world research settings, covering the most commonly used techniques. Packed with tips, data, and real-life examples, this handbook:

• Is current, covering practical synthetic chemistry the way it is practiced in research labs today, and addressing topics such as SciFinder and related searching, microwave chemistry, ultrasonication, and solvent purification without distillation

• Is comprehensive, taking the experimenter from the initial commercial compound and literature search all the way through to the full characterization of the pure product

• Is well organized, following the process that the chemist goes through, from initiating to completing a synthetic experiment

• Features insider tips and tricks that experienced synthetic chemists know

• Includes numerous illustrations, lists, tables, and charts, including a solvent selection chart that makes information instantly accessible

• Covers handling and preparing reagents, gases, and solvents, specific details for small-scale reactions, conducting the reaction (including temperature control), following up the reaction (including evaporation, vacuum, and purification), and identifying the product (including spectroscopy)

A thorough, accessible reference for organic chemists, laboratory technicians, or students, this guide merits a prominent place in every lab. It's also a great textbook for upper-level undergraduate and graduate students studying organic chemistry, medicine, pharmaceuticals, and polymers.

From the Inside Flap

How to Use the Solvent selection chart

Solvents known to swell polystyrene are shown in blue. Protic solvents are shown in red. Aprotic solvents are shown in black. N-methylformamide and N-methylacetamide are shown slightly lower than their t1 coordinates, 5.4 and 5.3, to compact the chart.

This chart is based on: "Screening of suitable solvents in organic synthesis. Strategies for solvent selection." Carlson, R.; Lunstedt, T.; Albano, C. Acta Chem. Scand. B 1985, 39, 79-91. This work used principal components analysis of solvent properties [mp, bp, dielectric constant (e), dipole moment (m), refractive index (h), ET (spectroscopically determined effect on a solvatochromatic dye), and log P]. The eigenvectors were projected into two dimensions, t1 and t2, representing a conflation of properties that most differentiate these solvents, accounting for ?80% of their variance. Polarity correlates with t1, while polarizability correlates with t2. Solvents in the vicinity of one another in this chart should have similar properties. Solvents are positioned approximately to improve clarity.

For reactions with a known solvent dependence, select solvents in the vicinity of the known best solvent(s).For reactions with an unknown solvent dependence:

a. Select solvents that give uniform coverage of the solvent space (i.e., a regular lattice with a density consistent with the number of experiments desired). Both aprotic and protic solvents might be selected when compatible with reaction conditions.

b. Select solvents as dissimilar as possible. A D-optimal design selects solvents at the extreme periphery of the solvent space. A quadratic D-optimal design also includes a solvent near the origin.

c. Select typical solvents from each class (polar/non-polar, protic/aprotic, etc.).

Edition details

• Publisher: Wiley-Interscience
• Publication date: 2007
• ISBN 10: 0470107073
• ISBN 13: 9780470107072
• Binding: Paperback
• Language: English
• Edition number: 1
• Number of pages: 208