Peptide and Protein Design for Biopharmaceutical Applications - Hardcover

Hardcover

ISBN 10: 0470319615 ISBN 13: 9780470319611

Publisher: John Wiley & Sons Inc, 2009

Synopsis

Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create ‘tailor-made’ peptides and proteins with improved pharmacological properties.

Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include:

• Computer modeling of peptides and proteins
• Peptidomimetics
• Design and synthesis of cyclic peptides
• Carbohydrates in peptide and protein design
• De novo design of peptides and proteins
• Medical development applications
• An extended case study – the design of insulin variants

Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry.

About this title

About the Author:

Knud J. Jensen, University of Copenhagen, Faculty of Life Sciences, Denmark
Professor Jensen's research interests cover synthetic bioorganic chemistry, peptide chemistry, carbohydrate chemistry, chemical protein synthesis, solid-phase synthesis and glycobiology.

Review:

"This book provides a comprehensive review of the many approaches undertaken over the yearsto develop peptide-based and peptide-mimetic-based drugs." (Journal of Medicinal Chemistry, June 2010)

About this edition

• Publisher: John Wiley & Sons Inc
• Publication date: 2009
• ISBN 10: 0470319615
• ISBN 13: 9780470319611
• Binding: Hardcover
• Number of pages: 294
• Editor: Jensen Knud J.