Kinetics of Enzyme Action: Essential Principles for Drug Hunters

3.5 avg rating
( 2 ratings by Goodreads )
 
9780470414118: Kinetics of Enzyme Action: Essential Principles for Drug Hunters

Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery.

"synopsis" may belong to another edition of this title.

From the Back Cover:

"Dr. Stein . . . make[s] a difficult topic easy to understand and comprehend."
Richard Harrison, Wyeth Research

Details on the approaches and applications essential to kinetically characterizing enzyme inhibitors for drug discovery

The ability of enzymes to bring about the transformation of one chemical substance into another makes them the favorite—and most productive—drug target in the pharmaceutical industry. Kinetics of Enzyme Action explores, in depth, the characteristics and applications of these proteins and their vital role in the development of new medicines by placing the subject of enzymology in a historical context that enriches and heightens understanding of this complex science. It introduces readers to a wide range of topics invaluable for helping them discover and kinetically characterize enzyme inhibitors—from simple, one-substrate enzyme reactions to the more complex two-substrate enzymes reactions. Some of the highlights in this book include:

  • A detailed description of enzyme kinetics as applied to drug discovery
  • A comprehensive collection of theory and pragmatic approaches to guide readers in the science of performing detailed enzyme mechanistic studies
  • An outline of the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery
  • Numerous case studies from scientific literature that bring the topics to life

From discussion of the early developments in the kinetics of enzymatic reactions to fresh insights on contemporary enzymology, Kinetics of Enzyme Action offers comprehensive coverage of a discipline that holds vital significance for all pharmaceutical practitioners.

About the Author:

ROSS L. STEIN received his PhD in physical organic chemistry from Indiana University in 1978, after which he conducted post-doctoral research in mechanistic enzymology at the University of Kansas. His career has included positions at Merck, where he headed the Enzymology Department, and ProScript (acquired by Millennium in 1999) as vice president of biochemistry. At ProScript, Dr. Stein was instrumental in the pre-clinical development and co-inventor of the drug VELCADETM, a proteasome inhibitor used to treat multiple myeloma. In 2001, he accepted a position at Harvard Medical School to establish and head the Laboratory for Drug Discovery in Neurodegeneration. Most recently, from 2009-2011, Dr. Stein was vice president of drug discovery at Sirtris Pharmaceuticals.

"About this title" may belong to another edition of this title.

Buy New View Book
List Price: US$ 102.95
US$ 74.45

Convert Currency

Shipping: FREE
From India to U.S.A.

Destination, Rates & Speeds

Add to Basket

Top Search Results from the AbeBooks Marketplace

1.

Stein Ross L.
ISBN 10: 0470414111 ISBN 13: 9780470414118
New Quantity Available: 5
Seller:
firstbookstore
(New Delhi, India)
Rating
[?]

Book Description Book Condition: Brand New. Brand New Original US Edition, Perfect Condition. Printed in English. Excellent Quality, Service and customer satisfaction guaranteed!. Bookseller Inventory # AIND-74265

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 74.45
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

2.

Dale
ISBN 10: 0470414111 ISBN 13: 9780470414118
New Quantity Available: 1
Seller:
Bookshub
(Karol Bagh, India)
Rating
[?]

Book Description Book Condition: New. New. US edition. Perfect condition. Customer satisfaction our priority. Bookseller Inventory # ABE-FEB-43928

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 77.82
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

3.

Stein R.L.
ISBN 10: 0470414111 ISBN 13: 9780470414118
New Quantity Available: 1
Seller:
Bookshub
(Karol Bagh, India)
Rating
[?]

Book Description Book Condition: New. New. US edition. Perfect condition. Customer satisfaction our priority. Bookseller Inventory # ABE-FEB-43929

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 77.82
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

4.

Dale
ISBN 10: 0470414111 ISBN 13: 9780470414118
New Quantity Available: 1
Seller:
EBOOKSTORE2010
(New Delhi, ND, India)
Rating
[?]

Book Description Book Condition: Brand New. New. US edition. Customer Satisfaction guaranteed!!. Bookseller Inventory # SHUB43928

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 77.87
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

5.

Stein R.L.
ISBN 10: 0470414111 ISBN 13: 9780470414118
New Quantity Available: 1
Seller:
EBOOKSTORE2010
(New Delhi, ND, India)
Rating
[?]

Book Description Book Condition: Brand New. New. US edition. Customer Satisfaction guaranteed!!. Bookseller Inventory # SHUB43929

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 77.87
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

6.

Stein Ross L.
ISBN 10: 0470414111 ISBN 13: 9780470414118
New Quantity Available: 5
Seller:
Romtrade Corp.
(STERLING HEIGHTS, MI, U.S.A.)
Rating
[?]

Book Description Book Condition: New. Brand New Original US Edition.We Ship to PO BOX Address also. EXPEDITED shipping option also available for faster delivery. Bookseller Inventory # AUSBNEW-74265

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 78.67
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

7.

Ross L. Stein
Published by Wiley-Blackwell 2011-08-05 (2011)
ISBN 10: 0470414111 ISBN 13: 9780470414118
New Quantity Available: 2
Seller:
Chiron Media
(Wallingford, United Kingdom)
Rating
[?]

Book Description Wiley-Blackwell 2011-08-05, 2011. Book Condition: New. Brand new book, sourced directly from publisher. Dispatch time is 24-48 hours from our warehouse. Book will be sent in robust, secure packaging to ensure it reaches you securely. Bookseller Inventory # NU-LBR-00958429

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 74.76
Convert Currency

Add to Basket

Shipping: US$ 3.95
From United Kingdom to U.S.A.
Destination, Rates & Speeds

8.

Ross L. Stein
Published by John Wiley and Sons Ltd, United States (2011)
ISBN 10: 0470414111 ISBN 13: 9780470414118
New Hardcover First Edition Quantity Available: 1
Seller:
The Book Depository US
(London, United Kingdom)
Rating
[?]

Book Description John Wiley and Sons Ltd, United States, 2011. Hardback. Book Condition: New. 1. Auflage. Language: English . Brand New Book. Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery. Bookseller Inventory # LIB9780470414118

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 80.34
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

9.

Dale
ISBN 10: 0470414111 ISBN 13: 9780470414118
New Quantity Available: 1
Seller:
Basi6 International
(Irving, TX, U.S.A.)
Rating
[?]

Book Description Book Condition: Brand New. New, US edition. Excellent Customer Service. Bookseller Inventory # ABEUSA-43928

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 81.28
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

10.

Stein R.L.
ISBN 10: 0470414111 ISBN 13: 9780470414118
New Quantity Available: 1
Seller:
Basi6 International
(Irving, TX, U.S.A.)
Rating
[?]

Book Description Book Condition: Brand New. New, US edition. Excellent Customer Service. Bookseller Inventory # ABEUSA-43929

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 81.28
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

There are more copies of this book

View all search results for this book