Zebrafish: Methods for Assessing Drug Safety and Toxicity

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9780470425138: Zebrafish: Methods for Assessing Drug Safety and Toxicity
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Zebrafish: Methods for Assessing Drug Safety and Toxicityoffers a practical guide for using zebrafish as a tool fortoxicology studies. 

Consolidating key protocols and approaches to help researchersnavigate the important and evolving field of zebrafish models fortoxicity screening, this new title describes the methods for usingthe zebrafish as a model organism to assess compound-inducedtoxicity on all major organs.  Individual chapters thatconcentrate on assays for each organ system are included andvarious analytical tools including microscopy, microplate readers,high content imaging systems, ECG, blood pressure monitors, highspeed video and motion detectors are described.

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Discover the benefits of using zebrafish as a model organism toassess compound-induced toxicity

Offering a broad range of methods, Zebrafish explains how toassess compound-induced toxicity in all major organs using thezebrafish as a model organism. The authors effectively demonstratewhy this vertebrate model offers compelling experimentaladvantages, including drug delivery directly in the fish water,small quantity of drug required per experiment, statisticallysignificant number of animals per test, and low cost. Moreover, theauthors describe how drug assessment can be performed usingwild-type, mutant, transgenic, and knock-down zebrafish models.

As a practical guide, this text brings together key findings,protocols, and approaches to support an important, rapidly emergingtool in toxicology research, including:

  • Methods to assess compound-induced toxicity in the heart, liver,kidney, central nervous system, eye, ear, hematopoietic system, aswell as on overall development

  • Chemical-induced disease models and phenocopies designed toidentify potential drug candidates

  • Additional analytical tools adapted for use with zebrafish,including ECG and motion detectors

  • Improvements in breeding and spawning that facilitateindustrial-scale screening

Zebrafish also examines such recent developments as the use ofzebrafish to assess the safety of nanoparticles. In addition, achapter is dedicated to compound screening for emerging cell-basedtherapies due to the zebrafish's unusual ability to regeneratetissue and organs.

The zebrafish model organism is increasingly used to assesscompound toxicity, safety, and efficacy, with numerous studiesconfirming that mammalian and zebrafish toxicity profiles arestrikingly similar. As the first single reference tocomprehensively review toxicity testing using zebrafish, the textis indispensable for anyone interested in taking full advantage ofthis highly effective and promising model organism.

About the Author:

Patricia McGrath, MBA, is President and CEO of Phylonix Pharmaceuticals, Inc. She has some twenty-five years of experience in high-tech and biotechnology management. Phylonix Pharmaceuticals develops and markets novel in vivo zebrafish-based assays for therapeutic and industrial screening for cancers, central nervous system and cardiovascular diseases, apoptosis, and toxicity.

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Book Description John Wiley and Sons Ltd, United States, 2012. Hardback. Condition: New. New. Language: English. Brand new Book. Zebrafish: Methods for Assessing Drug Safety and Toxicity offers a practical guide for using zebrafish as a tool for toxicology studies. Consolidating key protocols and approaches to help researchers navigate the important and evolving field of zebrafish models for toxicity screening, this new title describes the methods for using the zebrafish as a model organism to assess compound-induced toxicity on all major organs. Individual chapters that concentrate on assays for each organ system are included and various analytical tools including microscopy, microplate readers, high content imaging systems, ECG, blood pressure monitors, high speed video and motion detectors are described. Seller Inventory # APC9780470425138

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Book Description John Wiley and Sons Ltd, United States, 2012. Hardback. Condition: New. New. Language: English. Brand new Book. Zebrafish: Methods for Assessing Drug Safety and Toxicity offers a practical guide for using zebrafish as a tool for toxicology studies. Consolidating key protocols and approaches to help researchers navigate the important and evolving field of zebrafish models for toxicity screening, this new title describes the methods for using the zebrafish as a model organism to assess compound-induced toxicity on all major organs. Individual chapters that concentrate on assays for each organ system are included and various analytical tools including microscopy, microplate readers, high content imaging systems, ECG, blood pressure monitors, high speed video and motion detectors are described. Seller Inventory # APC9780470425138

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Book Description Wiley. Hardcover. Condition: New. 360 pages. Zebrafish: Methods for Assessing Drug Safety and Toxicity offers a practical guide for using zebrafish as a tool for toxicology studies. Consolidating key protocols and approaches to help researchers navigate the important and evolving field of zebrafish models for toxicity screening, this new title describes the methods for using the zebrafish as a model organism to assess compound-induced toxicity on all major organs. Individual chapters that concentrate on assays for each organ system are included and various analytical tools including microscopy, microplate readers, high content imaging systems, ECG, blood pressure monitors, high speed video and motion detectors are described. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Hardcover. Seller Inventory # 9780470425138

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