Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up - Hardcover

Harrington, Peter J.

Hardcover

ISBN 10: 047057755X ISBN 13: 9780470577554

Publisher: Wiley, 2011

Synopsis

There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today―the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs.

Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future.

Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

About this title

About the Author

Peter J. Harrington is the founder of Better Pharma Processes, LLC, a consulting firm specializing in pharmaceutical process design and development. From 1988–2008, he worked for the Syntex Technology Center, later Roche Colorado, as a research fellow. Dr. Harrington has more than fifty patents and research publications, including reviews and abstracts, as well as the book Transition Metals in Total Synthesis (Wiley).

From the Back Cover

Standardizes and expands upon information available in process patents for "blockbuster" drugs

There is a need to inform the public that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs.

Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Pharmaceutical Process Chemistry for Synthesis also:

• Presents detailed discussions of the published process chemistry of Lipitor®, Advair Diskus®, Prevacid®, Singulair®, Seroquel®, Effexor XR®, Lexapro®, and Actos®
• Aids in the implementation of green chemistry in pharmaceutical manufacturing by comparing and contrasting known multiple processes to the same target
• Summarizes the known process chemistry by discussing the advantages of one selected route for each drug
• Reflects the range of tasks assigned to process chemists i.e., manufacturing route selection, conversion of an intermediate to final target
• A multi-level table of contents and comprehensive index of reagents for rapid access to specific information

Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

From the Inside Flap

Standardizes and expands upon information available in process patents for blockbuster drugs

There is a need to inform the public that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today--the push for greener processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs.

Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Pharmaceutical Process Chemistry for Synthesis also:

• Presents detailed discussions of the published process chemistry of Lipitor(R), Advair Diskus(R), Prevacid(R), Singulair(R), Seroquel(R), Effexor XR(R), Lexapro(R), and Actos(R)
• Aids in the implementation of green chemistry in pharmaceutical manufacturing by comparing and contrasting known multiple processes to the same target
• Summarizes the known process chemistry by discussing the advantages of one selected route for each drug
• Reflects the range of tasks assigned to process chemists--i.e., manufacturing route selection, conversion of an intermediate to final target
• A multi-level table of contents and comprehensive index of reagents for rapid access to specific information

Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

Edition details

• Publisher: Wiley
• Publication date: 2011
• Language: English
• ISBN 10: 047057755X
• ISBN 13: 9780470577554
• Binding: Hardcover
• Edition number: 1
• Number of pages: 376