Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up

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9780470577554: Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up
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There is a need to explain that generic versions of a drug maynot be manufactured by the same process as brand-name drugs andthat the different processes may have dramatically differentenvironmental impacts. Two global forces are at oddstoday—the push for "greener" processes and the push for lowerdrug prices. This book brings this conflict into sharp focus bydiscussing in detail the published process chemistry fortop-selling small molecule drugs.

Providing insights about process route selection, choice ofreagents, and reaction conditions, Pharmaceutical ProcessChemistry for Synthesis guides process chemists in identifyingbest processes for manufacturing these blockbuster drugs as theylose patent protection. Further, it highlights the strategies andmethodology that might be useful for expediting the processresearch and development of the blockbusters of the future.

Written from a refreshingly objective perspective, this book isessential for process chemists who need to devise practicalsyntheses for increasingly complex drugs in a constantly decreasingtime frame.

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From the Back Cover:

Standardizes and expands upon information available in processpatents for "blockbuster" drugs

There is a need to inform the public that generic versions of adrug may not be manufactured by the same process as brand-namedrugs and that the different processes may have dramaticallydifferent environmental impacts. Two global forces are at oddstoday—the push for "greener" processes and the push for lowerdrug prices. This book brings this conflict into sharp focus bydiscussing in detail the published process chemistry fortop-selling small molecule drugs.

Providing insights about process route selection, choice ofreagents, and reaction conditions, Pharmaceutical Process Chemistryfor Synthesis guides process chemists in identifying best processesfor manufacturing these blockbuster drugs as they lose patentprotection. Further, it highlights the strategies and methodologythat might be useful for expediting the process research anddevelopment of the blockbusters of the future. PharmaceuticalProcess Chemistry for Synthesis also:

  • Presents detailed discussions of the published processchemistry of Lipitor®, Advair Diskus®, Prevacid®,Singulair®, Seroquel®, Effexor XR®, Lexapro®,and Actos®
  • Aids in the implementation of green chemistry in pharmaceuticalmanufacturing by comparing and contrasting known multiple processesto the same target
  • Summarizes the known process chemistry by discussing theadvantages of one selected route for each drug
  • Reflects the range of tasks assigned to processchemists—i.e., manufacturing route selection, conversion of anintermediate to final target
  • A multi-level table of contents and comprehensive index ofreagents for rapid access to specific information

Written from a refreshingly objective perspective, this book isessential for process chemists who need to devise practicalsyntheses for increasingly complex drugs in a constantly decreasingtime frame.

About the Author:

Peter J. Harrington is the founder of Better Pharma Processes, LLC, a consulting firm specializing in pharmaceutical process design and development. From 1988–2008, he worked for the Syntex Technology Center, later Roche Colorado, as a research fellow. Dr. Harrington has more than fifty patents and research publications, including reviews and abstracts, as well as the book Transition Metals in Total Synthesis (Wiley).

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Book Description Wiley. Hardcover. Condition: New. 376 pages. Dimensions: 11.1in. x 8.6in. x 1.0in.There is aneed to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds todaythe push for greener processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Hardcover. Seller Inventory # 9780470577554

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