An Introduction To High Content Screening: Imaging Technology, Assay Development, and Data Analysis in Biology and Drug Discovery

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9780470624562: An Introduction To High Content Screening: Imaging Technology, Assay Development, and Data Analysis in Biology and Drug Discovery


Using a collaborative and interdisciplinary author base with experience in the pharmaceutical industry and academia, this book is a practical resource for high content (HC) techniques.

· Instructs readers on the fundamentals of high content screening (HCS) techniques
· Focuses on practical and widely-used techniques like image processing and multiparametric assays
· Breaks down HCS into individual modules for training and connects them at the end
· Includes a tutorial chapter that works through sample HCS assays, glossary, and detailed appendices

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From the Back Cover:

Master the Power of High Content Screening

Although the level of interest and investment in high content (HC) technologies is growing rapidly, new users have been missing a standard and accessible introduction to the field. This book fills that need as a practical resource for HC techniques.

Using a collaborative and interdisciplinary author base with experience in the pharmaceutical industry and academia, this book focuses on the fundamental concepts, rather than advanced material. The major objectives for the book are to educate people about the basic principles underlying HC screening that are rarely (or never) discussed in many publications in the field, and to provide the technical training needed to enable readers to design and implement their own HC screens. These objectives are met through the main text of the book, a tutorial chapter and a detailed appendix.

· Instructs readers on the fundamentals of high content screening (HCS) techniques
· Focuses on practical and widely-used techniques like image processing and multiparametric assays
· Breaks down HCS into individual modules for training and connects them at the end
· Includes a tutorial chapter that works through sample HCS assays, glossary, and detailed appendices

About the Author:

Steven Haney is a Senior Research Advisor and Group Leader at Eli Lilly and Company. He edited the book High Content Screening: Science, Techniques, and Applications (Wiley, 2008).

Douglas Bowman
is an Associate Scientific Fellow at Takeda Pharmaceuticals.

Arijit Chakravarty
is the Director of Modeling and Simulation (DMPK) at Takeda Pharmaceuticals.

Anthony Davies
is Center Director, Translational Cell Imaging, Queensland University Of Technology, Queensland, Australia.

Caroline Shamu
is the Director of the ICCB-Longwood Screening Facility at Harvard Medical School.

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Editor: Steven A. Haney; Editor: Doug Bowman; Associate Editor: Arijit Chakravarty; Associate Editor: Anthony Davies; Associate Editor: Caroline Shamu
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