Toxicology and Risk Assessment: A Comprehensive Introduction - Hardcover

Hardcover

ISBN 10: 0470868937 ISBN 13: 9780470868935

Publisher: Wiley-Interscience, 2008

Synopsis

This new book, written by two outstanding scientists in the field,describes the basic principles of toxic mechanisms and organtoxicity, providing detailed information on specific mechanisms orchemicals for exemplification. The goal is to provide sufficientinformation that the reader becomes familiar with the basicconcepts in toxicology to enable him or her to understand the basicprinciples in toxicology and to evaluate the risks at givenexposures. With this basic understanding the reader also will beable to critically evaluate the available information on a chemicaland to identify data gaps.

In addition to the introductory chapters the book will offer thefollowing systematic information, presented in six specialsections:

• Principles in Toxicology
• Organ Toxicology
• Methods in Toxicology
• Risk Assessment
• Risk Management
• Toxicity of Chemicals

Fulfilling a demand for such a book, this will be a welcomedintroductory text for students and non-experts alike to focuson and understand the principles of hazard identification and riskassessment of toxicants. Relevant to all those studying toxicology,biochemistry, biology, medicine and chemistry, as well astoxicologists in hospitals, universities and in industry.

About this title

About the Author

Prof. Dr. Helmut Greim, Institut für Toxikologie und Umwelthygiene Technische Universität München, Germany

From the Back Cover

TOXICOLOGY AND RISK ASSESSMENT: A COMPREHENSIVE INTRODUCTION

HELMUT GREIM, Institut für Toxikologie und Umwelthygiene,Technische Universität München

ROBERT SNYDER, Environmental and Occupational Health SciencesInstitute, Rutgers, The State University of New Jersey

Toxicology is concerned with the health risks of human exposureto chemicals. It describes the adverse effects of chemicals in aqualitative sense, and with evaluating them quantitatively bydetermining how much of a chemical is required to produce a givenresponse.

Toxicology and Risk Assessment: A ComprehensiveIntroduction describes the basic concepts of toxicology, andaims to equip the reader with the skills required to evaluate risksat given exposures. Topics covered include:

• Principles in Toxicology: toxicokinetics includingabsorption, distribution, metabolism and excretion; the mechanismsthat lead to cytotoxicity, carcinogenicity and effects onreproduction; and the toxic effects of mixtures of chemicals
• Organ Toxicology: information on anatomy and physiologyof the major organs; why they are specific targets; and themechanisms of specific chemicals affecting these organs
• Methods in Toxicology: the commonly used methods usedfor toxicity testing, both in vivo and in vitro
• Risk Assessment: the concepts comprising hazardidentification, dose-response, and exposure assessment and thedifferent approaches for thresholded and non-thresholded effects.Recent molecular-biological results on cellular responses togenotoxic agents such as DNA-repair, halt of proliferation, andapoptosis that allow assumption of thresholded genotoxic effectsare also described
• Risk Management: US and European regulations forchemicals
• Toxicity of Chemicals: the toxic mechanisms and effectsof major groups of chemicals

Toxicology and Risk Assessment is an essential text forscientists in academia, industry and government agencies who wantto understand how our bodies respond to toxicants, and theprinciples used to assess the health risks of specific exposurescenarios.

Edition details

• Publisher: Wiley-Interscience
• Publication date: 2008
• Language: English
• ISBN 10: 0470868937
• ISBN 13: 9780470868935
• Binding: Hardcover
• Edition number: 1
• Number of pages: 698
• Editor: Greim Helmut, Snyder Robert