Apoptosis and the Immune System

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9780471012511: Apoptosis and the Immune System

Apoptosis and the Immune Response

Edited by Christopher D. Gregory

In this timely and important work, an international group of leading investigators takes a close and critical look at programmed cell death and its role in the development, function, and maintenance of the immune system. Along with covering the primary actions of apoptosis, the contributors probe its role in carcinogenesis and HIV-induced pathogenesis. By offering a broad range of views, Apoptosis and the Immune Response presents a current and complete picture of the various aspects and consequences of this phenomenon.

Apoptosis and the Immune Response begins with the theories surrounding apoptosis and then covers its basic mechanisms including the morphologic, biochemical, and genetic features. The book offers authoritative discussions on the role of apoptosis in the deletion of self-reactive lymphocytes, prevention of autoimmunity, termination of the immune response, death of T cells infected by the HIV virus, neoplasia, and the homeostatic regulation of the hematopoietic system.

In particular, this excellent reference critiques such topics as:
* Apoptosis in thymocytes in vivo and in vitro
* Bcl-2/T-cell transgenics
* The role of c-myc
* Fas/APO-1 antigens and their roles
* Transgenic models of B-cell tolerance and autoimmunity
* How apoptosis affects the pathogenesis of AIDS and the implications for therapy
* Triggers for apoptosis and survival
* Recognition of apoptotic cells by phagocytes
* Apoptosis in peritoneal autoreactive CD5+ B cells
* and more
With its diverse expertise and timely, clear-cut insights, Apoptosis and the Immune Response will prove to be an invaluable resource for immunologists, cell and developmental biologists, hematologists, and oncologists--as well as graduate students.

Cover Design: Janice Noto-Helmers

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From the Publisher:

The phenomenon of apoptosis is of particular importance in the development, function and maintenance of the immune system, where it is used as a means of establishing immune tolerance and may be induced as a means of killing virally infected and cancerous cells. Reviews the current literature and theories concerning apoptosis and specifically discusses its role in the deletion of self-reactive lymphocytes, the prevention of autoimmunity, the death of T cells infected by the HIV virus, termination of the immune response, neoplasia and the homeostatic regulation of the hematopoietic system.

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Published by Wiley-Liss (1995)
ISBN 10: 0471012513 ISBN 13: 9780471012511
New Hardcover First Edition Quantity Available: 1
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Irish Booksellers
(Rumford, ME, U.S.A.)
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Book Description Wiley-Liss, 1995. Hardcover. Book Condition: New. book. Bookseller Inventory # M0471012513

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