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All of the breadth and depth of organic drug synthesis-in one resource
This work offers a clear examination of the synthetic routes followed to prepare a range of compounds with assigned generic names. With drugs selected for the illustrative value of the chemistry used for synthesis, the book illustrates a great variety of organic transformations and structural classes of compounds.
Ideal for anyone learning or working in organic, medicinal, or pharmaceutical chemistry today, Strategies for Organic Drug Synthesis and Design includes:
* Coverage of carbocyclic and heterocyclic compounds-steroids, opioid analgesics, beta lactam antibiotics, and more
* Hundreds of reaction flow charts detailing routes used to prepare over 600 compounds
* Biological rationales for drug classes and actions of individual agents
* Capsule presentations of basic principles of drug action
* An extensive chemical reaction index with over 3,000 entries.
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The field of organic synthesis has influenced chemistry and in turn society in a profound number of areas, from the development of medicinal agents to an astonishing variety of polymers. This book focuses upon the strategies and organic transformations which have been used to prepare the various structural classes that have been investigated as drugs. Special attention is paid to clarifying individual reactions of the drugs, and the text includes an extensive "Reaction Index."About the Author:
DANIEL LEDNICER has devoted his career in both the private and public sectors to the search for new therapeutic agents. A former chemist and project officer at the National Cancer Institute, he has held the positions of director of chemical research at Mead Johnson, director of pharmaceutical sciences at Adria Laboratories, and pharmaceutical manager at Analytical Biochemistry Laboratories. He is the editor of the Wiley series The Organic Chemistry of Drug Synthesis.
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