Wiley is proud to announce the publication of the first ever broad-based textbook introduction to Bioinformatics and Functional Genomics by a trained biologist, experienced researcher, and award-winning instructor. In this new text, author Jonathan Pevsner, winner of the 2001 Johns Hopkins University "Teacher of the Year" award, explains problem-solving using bioinformatic approaches using real examples such as breast cancer, HIV-1, and retinal-binding protein throughout. His book includes 375 figures and over 170 tables. Each chapter includes: Problems, discussion of Pitfalls, Boxes explaining key techniques and math/stats principles, Summary, Recommended Reading list, and URLs for freely available software. The text is suitable for professionals and students at every level, including those with little to no background in computer science.
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"I was particularly impressed by the comprehensible and comprehensive treatment of BLAST - the best that I have seen. One is guided from choosing the appropriate type of BLAST program, database and search parameters through to refining and analysing the significance of the search results--all illustrated with clear examples." (David P. Leader, University of Glasgow)
Bioinformatics and Functional Genomics is a textbook for advanced undergraduate students, graduate students, and anyone involved in biomedical research. Bioinformatics represents a new field at the interface of the twentieth century revolutions in molecular biology and computers. A focus of this new discipline is the use of computer databases and computer algorithms to study proteins, genes, and the complete collections of genes that comprise an organism (genomes). A major challenge in biology is to make sense of the enormous quantities of sequence data and structural data that are being generated by genome sequencing projects and other molecular biology efforts. The tools of bioinformatics include computer programs that help to reveal fundamental mechanisms underlying biological problems related to the structure and function of macromolecules, biochemical pathways, disease processes, and evolution. The aim of the book is to explain both the theory and practice of bioinformatics and genomics. The book is especially designed to help the biologist use computer programs and databases to solve biological problems.
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