An Introduction to Tissue-Biomaterial Interactions - Hardcover

Dee, Kay C.; Puleo, David A.; Bizios, Rena

Hardcover

ISBN 10: 0471253944 ISBN 13: 9780471253945

Publisher: Wiley-Liss, 2002

Synopsis

An Introduction to Tissue-Biomaterial Interactions acquaints an undergraduate audience with the fundamental biological processes that influence these sophisticated, cutting-edge procedures. Chapters one through three provide more detail about the molecular-level events that happen at the tissue-implant interface, while chapters four through ten explore selected material, biological, and physiological consequences of these events. The importance of the body’s wound-healing response is emphasized throughout. Specific topics covered include:Structure and properties of biomaterials

• Proteins
• Protein-surface interactions
• Blood-biomaterial interactions
• Inflammation and infection
• The immune system
• Biomaterial responses to implantation
• Biomaterial surface engineering
• Intimal hyperplasia and osseointegration as examples of tissue-biomaterial interactions

The text also provides extensive coverage of the three pertinent interfaces between the body and the biomaterial, between the body and the living cells, and between the cells and the biomaterial that are critical in the development of tissue-engineered products that incorporate living cells within a biomaterial matrix. Ideal for a one-semester, biomedical engineering course, An Introduction to Tissue-Biomaterial Interactions provides a solid framework for understanding today’s and tomorrow’s implantable biomedical devices.

About this title

From the Author

Anybody who's ever picked a scab off their knee to see what's underneath, who's wondered why a small papercut can bleed so much, or who's wondered how an embedded splinter can cause so much pain and swelling, will hopefully find this book informative.
The interactions of tissues or blood with biomaterials or medical devices is an area of crucial importance to many medical technologies. The macroscopic, tissue-level events (bone resorption or growth, blood clotting, fibrous tissue encapsulation, etc.) that often determine the success or failure of medical devices or implants are, ultimately, derived from cellular- and molecular-level interactions with the tissue-implant interface. Tissue engineering, a rapidly-growing field of research and development, seeks to control the functions and assembly of living cells. A thorough understanding of fundamental biological mechanisms by which the human body reacts to foreign surfaces, cells, and molecules, is a crucial prerequisite for advanced study in tissue engineering as well as for the continued development of tissue-engineered products.

From the Back Cover

The interaction of tissue and synthetic material can be the pivotal element in the artificial replacement of a body part damaged by disease or trauma. Hip replacements, dental implants, pacemaker leads, vascular grafts, heart valves, and dialysis machines all involve microscopic, tissue-level events that determine the success or failure of such devices. An Introduction to Tissue-Biomaterial Interactions acquaints an undergraduate audience with the fundamental biological processes that influence these sophisticated, cutting-edge procedures.

Chapters one through three provide more detail about the molecular-level events that happen at the tissue-implant interface, while chapters four through ten explore selected material, biological, and physiological consequences of these events. The importance of the body's wound-healing response is emphasized throughout. Specific topics covered include:
* Structure and properties of biomaterials
* Proteins
* Protein-surface interactions
* Blood-biomaterial interactions
* Inflammation and infection
* The immune system
* Biomaterial responses to implantation
* Biomaterial surface engineering
* Intimal hyperplasia and osseointegration as examples of tissue-biomaterial interactions

The text also provides extensive coverage of the three pertinent interfaces between the body and the biomaterial, between the body and the living cells, and between the cells and the biomaterial that are critical in the development of tissue-engineered products that incorporate living cells within a biomaterial matrix.

Ideal for a one-semester, biomedical engineering course, An Introduction to Tissue-Biomaterial Interactions provides a solid framework for understanding today's and tomorrow's implantable biomedical devices.

Edition details

• Publisher: Wiley-Liss
• Publication date: 2002
• ISBN 10: 0471253944
• ISBN 13: 9780471253945
• Binding: Hardcover
• Language: English
• Edition number: 1
• Number of pages: 248