What's Wrong with My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice - Hardcover

Crawley, Jacqueline N.

Hardcover

ISBN 10: 0471316393 ISBN 13: 9780471316398

Publisher: Wiley-Liss, 2000

Synopsis

Transgenic and knockout mutations provide an important means for understanding gene function, as well as for developing therapies for genetic diseases. This engaging and informative book discusses the many advances in the field of transgenic technology that have enabled researchers to bring about various changes in the mouse genome. Equal emphasis is given to both the principles of transgenic and knockout methods and their applications. A clear and concise format provides researchers with a comprehensive review of the behavioral paradigms appropriate for analyzing mouse phenotypes.

What's Wrong with My Mouse? explains the differences between transgenic knockout mice and their wild-type controls, while providing critical information about gene function and expression. This volume recognizes that newly identified genes can provide useful insights into brain functioning, including brain malfunctioning in disease states. Written by a world-renowned expert in the field, the material also covers:
* How to generate a transgenic or knockout mouse
* functions (open field, holeboard, rotarod, balance, grip, circadian activity, etc.)
* Sensory abilities (olfaction, vision, hearing, taste, touch, nociception)
* Reproductive behavior, social behavior, and emotional behavior

Researchers in neuroscience, pharmacology, genetics, developmental biology, and cell biology will all find this book essential reading.

About this title

About the Author

Jacqueline N. Crawley, PhD, is Chief of the Laboratory of Behavioral Neuroscience at the National Institute of Mental Health; Adjunct Professor of Psychiatry and Psychology at the University of North Carolina at Chapel Hill; and Adjunct Professor of Pharmacology at Georgetown University. Dr. Crawley has published more than 200 peer-reviewed papers and 60 review articles. Her research has included rodent behavioral analyses of noradrenergic pathways; benzodiazepine receptor ligands; neuropeptide transmitters, including galanin and cholecystokinin; mouse genetic models of autism; and behavioral phenotyping of more than 30 lines of transgenic and knockout mice. Recent awards include the International Behavioral Neuroscience Society Myers Lifetime Achievement Award (2005), the Fleur Strand Summer Neuropeptide Conference Award (2005), the Howard Hughes Medical Institute Preceptor Award (2004), and the National Institute of Mental Health Director's Award (2002).

What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice, Second Edition has been written in Dr. Crawley's private capacity, outside of her professional position at the National Institutes of Health. The views expressed in this book do not necessarily represent the views of the National Institutes of Health or of the United States government.

Review

"Very timely and will enable the non-behavioral scientist to make informed decisions on what behavioral tests are needed and with whom they should collaborate."--Nature Neuroscience

"Overall an excellent book. The book succesfully brings together the field of behavioral neuroscience and the rewards and insights that can be gained using this approach. I would reccomend that every behavioral scientist has at least two copies, one for their own use and one that will be on permanent loan to their students, post-doctoral students,and colleagues in molecular biology."--TRENDS in Pharmacological Sciences

Edition details

• Publisher: Wiley-Liss
• Publication date: 2000
• ISBN 10: 0471316393
• ISBN 13: 9780471316398
• Binding: Hardcover
• Language: English
• Edition number: 1
• Number of pages: 368