The Amide Linkage: Structural Significance in Chemistry, Biochemistry, and Materials Science - Hardcover

Hardcover

ISBN 10: 0471358932 ISBN 13: 9780471358930

Publisher: Wiley-Interscience, 2000

Synopsis

The amide linkage is one of the most fundamental and widespread chemical bonds in nature, underlying the properties of a vast array of organic molecules, polymers, and materials, including peptides and proteins. Arthur Greenberg, Curt Breneman, and Joel Liebman’s peerless text provides comprehensive coverage of the experimental, structural, and computational findings that shed light on the chemical and physical properties of the amide linkage, as well as its emerging applications in materials and biotechnology.
Chapters in The Amide Linkage highlight how this chemical bond factors in the design of enzyme inhibitors, cyclic peptides, antibacterial agents, and emerging nanotechnology applications. This one-of-a-kind study also:

• Discusses selected aspects of chemical reactions, structure, bonding, and energetics of the amide bond, including amide rotational barriers, stereochemistry, complexation, spectroscopy, and thermochemistry
  
• Presents specific applications to supramolecular and stereospecific synthesis
  
• Discusses ke y aspects of peptide and protein chemistry–such as molecular recognition, conformation, and folding–in terms of the amide linkage
  
• Includes chapters contributed by numerous eminent chemists and biochemists

Organic, medicinal, polymer, and physical chemists, as well as biochemists and materials scientists, will find The Amide Linkage to be an invaluable addition to their professional libraries.

About this title

From the Back Cover

An authoritative reference to an important and ubiquitous chemical linkage
The amide linkage is one of the most fundamental and widespread chemical bonds in nature, underlying the properties of a vast array of organic molecules, polymers, and materials, including peptides and proteins. Arthur Greenberg, Curt Breneman, and Joel Liebman's peerless text provides comprehensive coverage of the experimental, structural, and computational findings that shed light on the chemical and physical properties of the amide linkage, as well as its emerging applications in materials and biotechnology.
Chapters in The Amide Linkage highlight how this chemical bond factors in the design of enzyme inhibitors, cyclic peptides, antibacterial agents, and emerging nanotechnology applications. This one-of-a-kind study also:
* Discusses selected aspects of chemical reactions, structure, bonding, and energetics of the amide bond, including amide rotational barriers, stereochemistry, complexation, spectroscopy, and thermochemistry
* Presents specific applications to supramolecular and stereospecific synthesis
* Discusses key aspects of peptide and protein chemistry-such as molecular recognition, conformation, and folding-in terms of the amide linkage
* Includes chapters contributed by numerous eminent chemists and biochemists
Organic, medicinal, polymer, and physical chemists, as well as biochemists and materials scientists, will find The Amide Linkage to be an invaluable addition to their professional libraries.

About the Author

ARTHUR GREENBERG, PhD, is Professor in the Department of Chemistry at the University of New Hampshire.

CURT M. BRENEMAN, PhD, is Professor in the Department of Chemistry at Rensselaer Polytechnic Institute.

JOEL F. LIEBMAN, PhD, is Professor in the Department of Chemistry and Biochemistry at the University of Maryland, Baltimore County.

Edition details

• Publisher: Wiley-Interscience
• Publication date: 2000
• ISBN 10: 0471358932
• ISBN 13: 9780471358930
• Binding: Hardcover
• Language: English
• Edition number: 1
• Number of pages: 672
• Editor: Greenberg Arthur, Breneman Curt M., Liebman Joel F.