Principles of Nuclear Structure and Function

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9780471415381: Principles of Nuclear Structure and Function

The nucleus guides the life processes of the cell by directing cellular reproduction, differentiation during development, and metabolism. The study of the structure and function of the nucleus along with its genetic material serves as the foundation for the science of genetics. Principles of Nuclear Structure and Function provides a comprehensive overview of the cell nucleus by illustrating the connection between function and the architecture of the nucleus.
Richly illustrated throughout, each chapter includes an overview, detailed examples, summary points, references, and callout boxes highlighting methods and cutting-edge technology. The appendix provides a useful list of related Web sites. Some of the subjects reviewed within Principles of Nuclear Structure and Function include:
* Nuclear structure, replication, damage, and repair
* Regulation of gene expression
* The cell cycle
* Meiosis and recombination
This timely volume presents functional studies within their proper structural context and is an informative profile of the cell and molecular biology in nuclei and chromatin. For those studying cell biology, along with molecular and cell biologists, geneticists, and reproductive biologists, Principles of Nuclear Structure and Function is a definitive resource.
Visit www.wiley.com/cook for supplementary information, including additional Web resources, downloadable figures, and discussion questions.

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From the Publisher:

I liked both the content and the layout of the book. It will be valuable to both the novice and the expert and may serve well as a text for focused graduate classes.--Gwen V. Childs, Ph.D., University of Arkansas for Medical Sciences, Little Rock, AR

Peter Cook presents an eloquent arguement for considering nuclear events from the holistic viewpoint of the particular structures and factories within which the events of transcription, recombination,replication and repair occur. This is a contemporary and well -informed perspective by a thought leader in this reasearch area, and provides a welcome contrast with the more reductionist views presented in most textbooks on this topic.--Alan Wolffe, Sangamo BioSciences, Richmond, California

From the Author:

By the end of the nineteenth century, biologists understood that the gross anatomy of an organism directly underpinned its life style. One hundred years later, we can carry this understanding all the way to the molecular level, relating the geometry of individual biomolecules to the way they carry out their functions. At an intermediate level, we expect different parts of the cell to perform different functions. The architecture of the mitochondrion is so exquisitely interlinked with energy production, and the cytoskeleton with cell support and movement, that discussing function without knowledge of structure is impossible. We would expect the same to apply to the nucleus, with clearly-defined regions carrying out specific functions; however, the nuclear interior is generally depicted in our textbooks as a featureless tangle of chromatin fibers. Of course, it is not like that. Indeed, recent research shows that it has a rich substructure; for example, active polymerases are attached to discrete structures within nuclei. This book is based on the belief that an understanding of nuclear function goes hand in hand with an understanding of nuclear architecture.

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